Gene therapy for infectious diseases

Bruce A. Bunnell, Richard A. Morgan

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Gene therapy is being investigated as an alternative treatment for a wide range of infectious diseases that are not amenable to standard clinical management. Approaches to gene therapy for infectious diseases can be divided into three broad categories: (i) gene therapies based on nucleic acid moieties, including antisense DNA or RNA, RNA decoys, and catalytic RNA moieties (ribozymes); (ii) protein approaches such as transdominant negative proteins and single-chain antibodies; and (iii) immunotherapeutic approaches involving genetic vaccines or pathogen-specific lymphocytes. It is further possible that combinations of the aforementioned approaches will be used simultaneously to inhibit multiple stages of the life cycle of the infectious agent.

Original languageEnglish
Pages (from-to)42-56
Number of pages15
JournalClinical Microbiology Reviews
Issue number1
StatePublished - Jan 1998


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