TY - JOUR
T1 - Gene diversity and estimation of genetic admixture among mexican-Americans of starr county, texas
AU - Cerda-Flores, R. M.
AU - Kshatriya, G. K.
AU - Bertin, T. K.
AU - Hewett-Emmett, D.
AU - Hanis, C. L.
AU - Chakraborty, R.
N1 - Funding Information:
This work was supported in part by the US Public Health Service Research Grants DK 34666, DK01748 and GM 41399 from the National Institutes of Health. We thank an anonymous reviewer for extensive editorial and other constructive suggestions on this paper.
PY - 1992
Y1 - 1992
N2 - The Mexican-Americans of Starr County, Texas, classified by sex and birth-place, were studied to determine the extent of genetic variation and contributions from ancestral populations such as Spanish, AmerIndian and West African. Using 21 genetic marker systems, genetic distance and diversity analyses indicate that subpopulations of Mexican-Americans in Starr County are similar, and that more than 99% of the total gene diversity (HT) can be attributed to individual variation within the population. Genetic admixture analysis shows the predominant influence comes from the Spanish, a lesser contribution from AmerIndians and a slight one from the West Africans. The contribution of the ancestral population to various subpopulations of the Mexican-Americans of Starr County is similar. The Mexican-Americans of Starr County are similar to the Mexican population from northeastern Mexico. The history of admixture is apparently old enough to have brought the entire Mexican-American gene pool to Hardy-Weinberg equilibrium. There is no non-random association of alleles among the genetic marker systems considered in the present study, in spite of the fact that this population is of admixed origin. These results, in aggregate, suggest genetic homogeneity of the Mexican-Americans of Starr County, Texas, and point towards the utility of this population for genetic and epidemiological studies.
AB - The Mexican-Americans of Starr County, Texas, classified by sex and birth-place, were studied to determine the extent of genetic variation and contributions from ancestral populations such as Spanish, AmerIndian and West African. Using 21 genetic marker systems, genetic distance and diversity analyses indicate that subpopulations of Mexican-Americans in Starr County are similar, and that more than 99% of the total gene diversity (HT) can be attributed to individual variation within the population. Genetic admixture analysis shows the predominant influence comes from the Spanish, a lesser contribution from AmerIndians and a slight one from the West Africans. The contribution of the ancestral population to various subpopulations of the Mexican-Americans of Starr County is similar. The Mexican-Americans of Starr County are similar to the Mexican population from northeastern Mexico. The history of admixture is apparently old enough to have brought the entire Mexican-American gene pool to Hardy-Weinberg equilibrium. There is no non-random association of alleles among the genetic marker systems considered in the present study, in spite of the fact that this population is of admixed origin. These results, in aggregate, suggest genetic homogeneity of the Mexican-Americans of Starr County, Texas, and point towards the utility of this population for genetic and epidemiological studies.
UR - http://www.scopus.com/inward/record.url?scp=0026889180&partnerID=8YFLogxK
U2 - 10.1080/03014469200002222
DO - 10.1080/03014469200002222
M3 - Article
C2 - 1616290
AN - SCOPUS:0026889180
SN - 0301-4460
VL - 19
SP - 347
EP - 360
JO - Annals of Human Biology
JF - Annals of Human Biology
IS - 4
ER -