Future Directions for Pharmacogenetics

Michael W. Jann, Y. W.Francis Lam

Research output: Contribution to journalArticle

Abstract

The discipline of pharmacogenetics will continue to expand as scientific and clinical investigations increase our understanding of genetic variabilities in drug metabolism and response. These research efforts will include determination of molecular mechanisms for the different polymorphisms and evaluation of their clinical significance. The availability of molecular methodologies such as restriction fragment length polymorphisms analysis, polymerase chain reaction, and expression of cDNAs in cell cultures will further the investigative work in detection of normal and mutant alleles, identification of new substrates for different polymorphic metabolizing enzymes, and evaluation of mechanisms of individual susceptibility to biological disorders. Other areas such as the role of pharmacogenetics in drug development and regulatory control, in evaluation of potential drug-drug interactions, ethnic variation in polymorphic metabolism, and response, also need to be evaluated.

Original languageEnglish
Pages (from-to)44-46
Number of pages3
JournalJournal of Pharmacy Practice
Volume6
Issue number1
DOIs
StatePublished - Feb 1993

Fingerprint

Pharmacogenetics
Drug Evaluation
Drug Interactions
Restriction Fragment Length Polymorphisms
Pharmaceutical Preparations
Complementary DNA
Cell Culture Techniques
Alleles
Polymerase Chain Reaction
Enzymes
Research
Direction compound

Cite this

Jann, Michael W. ; Lam, Y. W.Francis. / Future Directions for Pharmacogenetics. In: Journal of Pharmacy Practice. 1993 ; Vol. 6, No. 1. pp. 44-46.
@article{16093478ff2b463d9d30ba49287591e8,
title = "Future Directions for Pharmacogenetics",
abstract = "The discipline of pharmacogenetics will continue to expand as scientific and clinical investigations increase our understanding of genetic variabilities in drug metabolism and response. These research efforts will include determination of molecular mechanisms for the different polymorphisms and evaluation of their clinical significance. The availability of molecular methodologies such as restriction fragment length polymorphisms analysis, polymerase chain reaction, and expression of cDNAs in cell cultures will further the investigative work in detection of normal and mutant alleles, identification of new substrates for different polymorphic metabolizing enzymes, and evaluation of mechanisms of individual susceptibility to biological disorders. Other areas such as the role of pharmacogenetics in drug development and regulatory control, in evaluation of potential drug-drug interactions, ethnic variation in polymorphic metabolism, and response, also need to be evaluated.",
author = "Jann, {Michael W.} and Lam, {Y. W.Francis}",
year = "1993",
month = "2",
doi = "10.1177/089719009300600105",
language = "English",
volume = "6",
pages = "44--46",
journal = "Journal of Pharmacy Practice",
issn = "0897-1900",
publisher = "SAGE Publications Inc.",
number = "1",

}

Future Directions for Pharmacogenetics. / Jann, Michael W.; Lam, Y. W.Francis.

In: Journal of Pharmacy Practice, Vol. 6, No. 1, 02.1993, p. 44-46.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Future Directions for Pharmacogenetics

AU - Jann, Michael W.

AU - Lam, Y. W.Francis

PY - 1993/2

Y1 - 1993/2

N2 - The discipline of pharmacogenetics will continue to expand as scientific and clinical investigations increase our understanding of genetic variabilities in drug metabolism and response. These research efforts will include determination of molecular mechanisms for the different polymorphisms and evaluation of their clinical significance. The availability of molecular methodologies such as restriction fragment length polymorphisms analysis, polymerase chain reaction, and expression of cDNAs in cell cultures will further the investigative work in detection of normal and mutant alleles, identification of new substrates for different polymorphic metabolizing enzymes, and evaluation of mechanisms of individual susceptibility to biological disorders. Other areas such as the role of pharmacogenetics in drug development and regulatory control, in evaluation of potential drug-drug interactions, ethnic variation in polymorphic metabolism, and response, also need to be evaluated.

AB - The discipline of pharmacogenetics will continue to expand as scientific and clinical investigations increase our understanding of genetic variabilities in drug metabolism and response. These research efforts will include determination of molecular mechanisms for the different polymorphisms and evaluation of their clinical significance. The availability of molecular methodologies such as restriction fragment length polymorphisms analysis, polymerase chain reaction, and expression of cDNAs in cell cultures will further the investigative work in detection of normal and mutant alleles, identification of new substrates for different polymorphic metabolizing enzymes, and evaluation of mechanisms of individual susceptibility to biological disorders. Other areas such as the role of pharmacogenetics in drug development and regulatory control, in evaluation of potential drug-drug interactions, ethnic variation in polymorphic metabolism, and response, also need to be evaluated.

UR - http://www.scopus.com/inward/record.url?scp=84965451258&partnerID=8YFLogxK

U2 - 10.1177/089719009300600105

DO - 10.1177/089719009300600105

M3 - Article

AN - SCOPUS:84965451258

VL - 6

SP - 44

EP - 46

JO - Journal of Pharmacy Practice

JF - Journal of Pharmacy Practice

SN - 0897-1900

IS - 1

ER -