Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method

Fan Zhang, Zhicheng Liu, Xia Li, Zhiwen Gao, Xuan Su

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

GPCRs are physiologically significant receptors linked to numerous diseases Including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and Its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the Interactions upon which G protein signaling pathways are built Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.

Original languageEnglish
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages4767-4770
Number of pages4
StatePublished - 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: 1 Sep 20054 Sep 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period1/09/054/09/05

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  • Cite this

    Zhang, F., Liu, Z., Li, X., Gao, Z., & Su, X. (2005). Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 4767-4770). [1615537] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).