Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method

Fan Zhang; Zhicheng Liu; Xia Li; Zhiwen Gao; Xuan Su

Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method

Fan Zhang, Zhicheng Liu, Xia Li, Zhiwen Gao, Xuan Su

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

GPCRs are physiologically significant receptors linked to numerous diseases Including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and Its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the Interactions upon which G protein signaling pathways are built Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.

Original language	English
Title of host publication	Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages	4767-4770
Number of pages	4
State	Published - 2005
Event	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China Duration: 1 Sep 2005 → 4 Sep 2005

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	7 VOLS
ISSN (Print)	0589-1019

Other

Other	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Country	China
City	Shanghai
Period	1/09/05 → 4/09/05

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Zhang, F., Liu, Z., Li, X., Gao, Z., & Su, X. (2005). Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 4767-4770). [1615537] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Zhang, Fan ; Liu, Zhicheng ; Li, Xia ; Gao, Zhiwen ; Su, Xuan. / Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method. Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. pp. 4767-4770 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

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title = "Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method",

abstract = "GPCRs are physiologically significant receptors linked to numerous diseases Including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and Its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the Interactions upon which G protein signaling pathways are built Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.",

author = "Fan Zhang and Zhicheng Liu and Xia Li and Zhiwen Gao and Xuan Su",

year = "2005",

language = "English",

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series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

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Zhang, F, Liu, Z, Li, X, Gao, Z & Su, X 2005, Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method. in Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005., 1615537, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 7 VOLS, pp. 4767-4770, 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, China, 1/09/05.

Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method. / Zhang, Fan; Liu, Zhicheng; Li, Xia; Gao, Zhiwen; Su, Xuan.

Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 4767-4770 1615537 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N2 - GPCRs are physiologically significant receptors linked to numerous diseases Including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and Its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the Interactions upon which G protein signaling pathways are built Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.

AB - GPCRs are physiologically significant receptors linked to numerous diseases Including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and Its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the Interactions upon which G protein signaling pathways are built Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.

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Zhang F, Liu Z, Li X, Gao Z, Su X. Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 4767-4770. 1615537. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).