TY - GEN
T1 - Functional site analysis in proteins of G protein signaling pathways using fuzzy evolutionary trace method
AU - Zhang, Fan
AU - Liu, Zhicheng
AU - Li, Xia
AU - Gao, Zhiwen
AU - Su, Xuan
PY - 2005
Y1 - 2005
N2 - GPCRs are physiologically significant receptors linked to numerous diseases Including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and Its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the Interactions upon which G protein signaling pathways are built Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.
AB - GPCRs are physiologically significant receptors linked to numerous diseases Including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and Its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the Interactions upon which G protein signaling pathways are built Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.
UR - http://www.scopus.com/inward/record.url?scp=33846903580&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33846903580
SN - 0780387406
SN - 9780780387409
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 4767
EP - 4770
BT - Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
T2 - 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Y2 - 1 September 2005 through 4 September 2005
ER -