Functional connectivity between the left and right inferior frontal lobes in a small sample of children with and without reading difficulties

Emily A. Farris, Timothy N. Odegard, Haylie Lauren Miller, Jeremiah Ring, Greg Allen, Jeffrey Black

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Individuals with dyslexia often demonstrate bilateral inferior frontal lobe activation while performing basic reading tasks. To investigate these findings, functional connectivity analyses were conducted on fMRI data collected from children with dyslexia, who did and did not respond well to treatment, and from non-impaired readers. Analysis of active and resting-state fMRI data across 15 participants revealed functional connections between the inferior frontal regions in non-impaired readers and treatment responders, but not in treatment non-responders. Analyses incorporating DTI data revealed associations with anterior corpus callosum structures. These results suggest that bilateral frontal functional connectivity is normative and may facilitate treatment response.

Original languageEnglish
Pages (from-to)425-439
Number of pages15
JournalNeurocase
Volume17
Issue number5
DOIs
StatePublished - 1 Oct 2011

Keywords

  • Cognition
  • Dyslexia
  • Neuroimaging
  • Neuroscience
  • Reading

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