TY - JOUR
T1 - Frequencies of complex diseases in hybrid populations
AU - Chakraborty, Ranajit
AU - Weiss, Kenneth M.
PY - 1986/8
Y1 - 1986/8
N2 - Diseases of complex etiology demonstrate considerable variation in their frequencies in different ethnic populations. Noninsulin‐dependent diabetes mellitus (NIDDM), rheumatoid arthritis, and several cardiovascular diseases constitute examples of such disorders. In genetic studies involving hybrid populations of known ancestry, it is of interest to compare and correlate disease prevalence with the admixture proportion, the latter estimated from a number of polymorphic genetic markers. Theoretical formulations are provided relating disease prevalence in a hybrid population to the admixture proportion under different models of disease transmission. It is shown that the relationship between admixture proportion and disease frequency provides discriminatory power regarding the mode of inheritance. This method is illustrated with an example comparing the proportion of Amerindian ancestry in Mexican‐Americans and the prevalence of NIDDM. It is found that genetic factors are involved in susceptibility to NIDDM, but the mode of inheritance cannot be explained by any simple genetic model, and the role of sporadic events cannot be totally ruled out.
AB - Diseases of complex etiology demonstrate considerable variation in their frequencies in different ethnic populations. Noninsulin‐dependent diabetes mellitus (NIDDM), rheumatoid arthritis, and several cardiovascular diseases constitute examples of such disorders. In genetic studies involving hybrid populations of known ancestry, it is of interest to compare and correlate disease prevalence with the admixture proportion, the latter estimated from a number of polymorphic genetic markers. Theoretical formulations are provided relating disease prevalence in a hybrid population to the admixture proportion under different models of disease transmission. It is shown that the relationship between admixture proportion and disease frequency provides discriminatory power regarding the mode of inheritance. This method is illustrated with an example comparing the proportion of Amerindian ancestry in Mexican‐Americans and the prevalence of NIDDM. It is found that genetic factors are involved in susceptibility to NIDDM, but the mode of inheritance cannot be explained by any simple genetic model, and the role of sporadic events cannot be totally ruled out.
KW - Admixed populations
KW - Complex etiology
KW - Mexican‐Americans
KW - Type II diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0022468358&partnerID=8YFLogxK
U2 - 10.1002/ajpa.1330700408
DO - 10.1002/ajpa.1330700408
M3 - Article
C2 - 3766715
AN - SCOPUS:0022468358
SN - 0002-9483
VL - 70
SP - 489
EP - 503
JO - American Journal of Physical Anthropology
JF - American Journal of Physical Anthropology
IS - 4
ER -