Forensic validation of the STR systems SE 33 and TC 11

P. Wiegand; Bruce Budowle; S. Rand; B. Brinkmann

doi:10.1007/BF01222114

Forensic validation of the STR systems SE 33 and TC 11

P. Wiegand, Bruce Budowle, S. Rand, B. Brinkmann

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159 Scopus citations

Abstract

Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.

Original language	English
Pages (from-to)	315-320
Number of pages	6
Journal	International Journal of Legal Medicine
Volume	105
Issue number	6
DOIs	https://doi.org/10.1007/BF01222114
State	Published - 1 Nov 1993

Keywords

Forensic validation
Population studies
SE 33
Short tandem repeats
TC 11

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10.1007/BF01222114

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title = "Forensic validation of the STR systems SE 33 and TC 11",

abstract = "Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.",

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AU - Wiegand, P.

AU - Budowle, Bruce

AU - Rand, S.

AU - Brinkmann, B.

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N2 - Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.

AB - Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.

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