Forensic validation of the STR systems SE 33 and TC 11

P. Wiegand; Bruce Budowle; S. Rand; B. Brinkmann

doi:10.1007/BF01222114

Forensic validation of the STR systems SE 33 and TC 11

P. Wiegand, Bruce Budowle, S. Rand, B. Brinkmann

Research output: Contribution to journal › Article › peer-review

165 Scopus citations

Abstract

Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.

Original language	English
Pages (from-to)	315-320
Number of pages	6
Journal	International Journal of Legal Medicine
Volume	105
Issue number	6
DOIs	https://doi.org/10.1007/BF01222114
State	Published - 1 Nov 1993

Keywords

Forensic validation
Population studies
SE 33
Short tandem repeats
TC 11

Access to Document

10.1007/BF01222114

Cite this

@article{9cb09b0a5f05419fbcf292a236b21bdf,

title = "Forensic validation of the STR systems SE 33 and TC 11",

abstract = "Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.",

keywords = "Forensic validation, Population studies, SE 33, Short tandem repeats, TC 11",

author = "P. Wiegand and Bruce Budowle and S. Rand and B. Brinkmann",

year = "1993",

month = nov,

day = "1",

doi = "10.1007/BF01222114",

language = "English",

volume = "105",

pages = "315--320",

journal = "International Journal of Legal Medicine",

issn = "0937-9827",

publisher = "Springer Verlag",

number = "6",

}

TY - JOUR

T1 - Forensic validation of the STR systems SE 33 and TC 11

AU - Wiegand, P.

AU - Budowle, Bruce

AU - Rand, S.

AU - Brinkmann, B.

PY - 1993/11/1

Y1 - 1993/11/1

N2 - Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.

AB - Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.

KW - Forensic validation

KW - Population studies

KW - SE 33

KW - Short tandem repeats

KW - TC 11

UR - http://www.scopus.com/inward/record.url?scp=0027285464&partnerID=8YFLogxK

U2 - 10.1007/BF01222114

DO - 10.1007/BF01222114

M3 - Article

C2 - 8518197

AN - SCOPUS:0027285464

VL - 105

SP - 315

EP - 320

JO - International Journal of Legal Medicine

JF - International Journal of Legal Medicine

SN - 0937-9827

IS - 6

ER -

Forensic validation of the STR systems SE 33 and TC 11

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this