Forensic validation of the STR systems SE 33 and TC 11

P. Wiegand, Bruce Budowle, S. Rand, B. Brinkmann

Research output: Contribution to journalArticle

159 Scopus citations

Abstract

Population studies on Caucasians from northwest Germany were carried out using the short tandem repeat (STR) systems SE 33 (Locus: ACTBP2) and TC 11 (Locus: 11p15.5). After electrophoresis in PAG 26 alleles could be identified for SE 33 in a sample size of 180 unrelated individuals and 6 alleles were found for TC 11 in 110 individuals. The combined mean exclusion chance for both systems was 0.96 and the discrimination index 0.999. No significant deviations from Hardy-Weinberg equilibrium could be demonstrated. In a small sample of families (SE 33 -n = 21; TC 11 -n = 30) no new mutations could be found. Positive and reproducible results for both STRs could be obtained from 50 pg template DNA.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalInternational Journal of Legal Medicine
Volume105
Issue number6
DOIs
StatePublished - 1 Nov 1993

Keywords

  • Forensic validation
  • Population studies
  • SE 33
  • Short tandem repeats
  • TC 11

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