Fluorescent nanodiamonds for ultrasensitive detection

Joseph Kimball, Dmytro Shumilov, Badri Maliwa, T. W. Zerda, Bibhu Rout, Rafal Fudala, Sangram Limbaji Raut, Ignacy Gryczynski, Eric Simanek, Julian Borejdo, Ryan Rich, Irina Akopova, Zygmunt Gryczynski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Fluorescent nanodiamonds (NDs) are new and emerging nanomaterials that have potential to be used as fluorescence imaging agents and also as a highly versatile platform for the controlled functionalization and delivery of a wide spectrum of therapeutic agents. We will utilize two experimental methods, TIRF, a relatively simple method based on total internal reflection fluorescence and SPRF, fluorescence enhanced by resonance coupling with surface plasmons. We estimate that the SPRF method will be 100 times sensitive than currently available similar detectors based on detectors. The ultimate goal of this research is to develop microarray platforms that could be used for sensitive, fast and inexpensive gene sequencing and protein detection.

Original languageEnglish
Title of host publicationSingle Molecule Spectroscopy and Superresolution Imaging VII
PublisherSPIE
ISBN (Print)9780819498632
DOIs
StatePublished - 1 Jan 2014
EventSingle Molecule Spectroscopy and Superresolution Imaging VII - San Francisco, CA, United States
Duration: 1 Feb 20142 Feb 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8950
ISSN (Print)1605-7422

Other

OtherSingle Molecule Spectroscopy and Superresolution Imaging VII
CountryUnited States
CitySan Francisco, CA
Period1/02/142/02/14

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Keywords

  • Nanodiamonds
  • SPRF
  • TIRF

Cite this

Kimball, J., Shumilov, D., Maliwa, B., Zerda, T. W., Rout, B., Fudala, R., Raut, S. L., Gryczynski, I., Simanek, E., Borejdo, J., Rich, R., Akopova, I., & Gryczynski, Z. (2014). Fluorescent nanodiamonds for ultrasensitive detection. In Single Molecule Spectroscopy and Superresolution Imaging VII [89501H] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8950). SPIE. https://doi.org/10.1117/12.2045376