Fluorescent nanodiamonds for ultrasensitive detection

Joseph Kimball; Dmytro Shumilov; Badri Maliwa; T. W. Zerda; Bibhu Rout; Rafal Fudala; Sangram Limbaji Raut; Ignacy Gryczynski; Eric Simanek; Julian Borejdo; Ryan Rich; Irina Akopova; Zygmunt Gryczynski

doi:10.1117/12.2045376

Fluorescent nanodiamonds for ultrasensitive detection

Joseph Kimball, Dmytro Shumilov, Badri Maliwa, T. W. Zerda, Bibhu Rout, Rafal Fudala, Sangram Limbaji Raut, Ignacy Gryczynski, Eric Simanek, Julian Borejdo, Ryan Rich, Irina Akopova, Zygmunt Gryczynski

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Fluorescent nanodiamonds (NDs) are new and emerging nanomaterials that have potential to be used as fluorescence imaging agents and also as a highly versatile platform for the controlled functionalization and delivery of a wide spectrum of therapeutic agents. We will utilize two experimental methods, TIRF, a relatively simple method based on total internal reflection fluorescence and SPRF, fluorescence enhanced by resonance coupling with surface plasmons. We estimate that the SPRF method will be 100 times sensitive than currently available similar detectors based on detectors. The ultimate goal of this research is to develop microarray platforms that could be used for sensitive, fast and inexpensive gene sequencing and protein detection.

Original language	English
Title of host publication	Single Molecule Spectroscopy and Superresolution Imaging VII
Publisher	SPIE
ISBN (Print)	9780819498632
DOIs	https://doi.org/10.1117/12.2045376
State	Published - 1 Jan 2014
Event	Single Molecule Spectroscopy and Superresolution Imaging VII - San Francisco, CA, United States Duration: 1 Feb 2014 → 2 Feb 2014

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8950
ISSN (Print)	1605-7422

Other

Other	Single Molecule Spectroscopy and Superresolution Imaging VII
Country/Territory	United States
City	San Francisco, CA
Period	1/02/14 → 2/02/14

Keywords

Nanodiamonds
SPRF
TIRF

Access to Document

10.1117/12.2045376

Cite this

Kimball, J., Shumilov, D., Maliwa, B., Zerda, T. W., Rout, B., Fudala, R., Raut, S. L., Gryczynski, I., Simanek, E., Borejdo, J., Rich, R., Akopova, I., & Gryczynski, Z. (2014). Fluorescent nanodiamonds for ultrasensitive detection. In Single Molecule Spectroscopy and Superresolution Imaging VII [89501H] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8950). SPIE. https://doi.org/10.1117/12.2045376

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title = "Fluorescent nanodiamonds for ultrasensitive detection",

abstract = "Fluorescent nanodiamonds (NDs) are new and emerging nanomaterials that have potential to be used as fluorescence imaging agents and also as a highly versatile platform for the controlled functionalization and delivery of a wide spectrum of therapeutic agents. We will utilize two experimental methods, TIRF, a relatively simple method based on total internal reflection fluorescence and SPRF, fluorescence enhanced by resonance coupling with surface plasmons. We estimate that the SPRF method will be 100 times sensitive than currently available similar detectors based on detectors. The ultimate goal of this research is to develop microarray platforms that could be used for sensitive, fast and inexpensive gene sequencing and protein detection.",

keywords = "Nanodiamonds, SPRF, TIRF",

author = "Joseph Kimball and Dmytro Shumilov and Badri Maliwa and Zerda, {T. W.} and Bibhu Rout and Rafal Fudala and Raut, {Sangram Limbaji} and Ignacy Gryczynski and Eric Simanek and Julian Borejdo and Ryan Rich and Irina Akopova and Zygmunt Gryczynski",

year = "2014",

month = jan,

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doi = "10.1117/12.2045376",

language = "English",

isbn = "9780819498632",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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booktitle = "Single Molecule Spectroscopy and Superresolution Imaging VII",

note = "Single Molecule Spectroscopy and Superresolution Imaging VII ; Conference date: 01-02-2014 Through 02-02-2014",

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Kimball, J, Shumilov, D, Maliwa, B, Zerda, TW, Rout, B, Fudala, R, Raut, SL, Gryczynski, I, Simanek, E, Borejdo, J, Rich, R, Akopova, I & Gryczynski, Z 2014, Fluorescent nanodiamonds for ultrasensitive detection. in Single Molecule Spectroscopy and Superresolution Imaging VII., 89501H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8950, SPIE, Single Molecule Spectroscopy and Superresolution Imaging VII, San Francisco, CA, United States, 1/02/14. https://doi.org/10.1117/12.2045376

Fluorescent nanodiamonds for ultrasensitive detection. / Kimball, Joseph; Shumilov, Dmytro; Maliwa, Badri et al.
Single Molecule Spectroscopy and Superresolution Imaging VII. SPIE, 2014. 89501H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8950).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Shumilov, Dmytro

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AU - Zerda, T. W.

AU - Rout, Bibhu

AU - Fudala, Rafal

AU - Raut, Sangram Limbaji

AU - Gryczynski, Ignacy

AU - Simanek, Eric

AU - Borejdo, Julian

AU - Rich, Ryan

AU - Akopova, Irina

AU - Gryczynski, Zygmunt

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PB - SPIE

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Fluorescent nanodiamonds for ultrasensitive detection

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