Fluorescence quenching/enhancement surface assays: Signal manipulation using silver-coated gold nanoparticles

Evgenia G. Matveeva, Tanya Shtoyko, Ignacy Gryczynski, Irina Akopova, Zygmunt Gryczynski

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Gold nanoparticles covalently attached to the indium tin oxide coated glass slide drastically quench fluorescence of a surface immunoassay (approximately 5-fold). Silver electrochemically deposited over the gold particles leads to fluorescence amplification: signal increases approximately 7-8 times if compared to the signal on gold particles not covered with silver. This phenomenon allows enhancing of the surface immunoassays utilizing both types of nanoparticles.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalChemical Physics Letters
Volume454
Issue number1-3
DOIs
StatePublished - 10 Mar 2008

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