Abstract
C57BL/6NNia and autoimmune NZB/B1NJ mice aged 12-14 months were tested for acquisition and retention of an active avoidance response following vehicle or flumazenil (40 mg/kg), a benzodiazepine antagonist. Acquisition and retention performance was improved in flumazenil-treated mice when compared with vehicle-treated mice, although the degree of improvement varied with the level of performance in vehicle-treated mice of each strain. The NZB/B1NJ mice, which generally performed more poorly than the C57BL/6NNia mice, showed the greater improvements following flumazenil. These results suggest that antagonism of benzodiazepine receptors leads to improved learning and/or memory performance in mice with spontaneous age-associated deficits.
Original language | English |
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Pages (from-to) | 747-750 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 35 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1990 |
Keywords
- Aging
- Amnesia
- Autoimmunity
- Avoidance learning
- Benzodiazepine receptor antagonist
- C57BL/6NNia mice
- Cognitive decline
- Flumazenil
- Memory
- NZB/B1NJ mice