Flumazenil improves active avoidance performance in aging NZB/B1NJ and C57BL/6NNia mice

Harbans Lal; Michael J. Forster

doi:10.1016/0091-3057(90)90319-D

Flumazenil improves active avoidance performance in aging NZB/B1NJ and C57BL/6NNia mice

Harbans Lal, Michael J. Forster

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

C57BL/6NNia and autoimmune NZB/B1NJ mice aged 12-14 months were tested for acquisition and retention of an active avoidance response following vehicle or flumazenil (40 mg/kg), a benzodiazepine antagonist. Acquisition and retention performance was improved in flumazenil-treated mice when compared with vehicle-treated mice, although the degree of improvement varied with the level of performance in vehicle-treated mice of each strain. The NZB/B1NJ mice, which generally performed more poorly than the C57BL/6NNia mice, showed the greater improvements following flumazenil. These results suggest that antagonism of benzodiazepine receptors leads to improved learning and/or memory performance in mice with spontaneous age-associated deficits.

Original language	English
Pages (from-to)	747-750
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(90)90319-D
State	Published - Mar 1990

Keywords

Aging
Amnesia
Autoimmunity
Avoidance learning
Benzodiazepine receptor antagonist
C57BL/6NNia mice
Cognitive decline
Flumazenil
Memory
NZB/B1NJ mice

Access to Document

10.1016/0091-3057(90)90319-D

Cite this

@article{d0ffad5867ae4508aaf200c7615c64a7,

title = "Flumazenil improves active avoidance performance in aging NZB/B1NJ and C57BL/6NNia mice",

abstract = "C57BL/6NNia and autoimmune NZB/B1NJ mice aged 12-14 months were tested for acquisition and retention of an active avoidance response following vehicle or flumazenil (40 mg/kg), a benzodiazepine antagonist. Acquisition and retention performance was improved in flumazenil-treated mice when compared with vehicle-treated mice, although the degree of improvement varied with the level of performance in vehicle-treated mice of each strain. The NZB/B1NJ mice, which generally performed more poorly than the C57BL/6NNia mice, showed the greater improvements following flumazenil. These results suggest that antagonism of benzodiazepine receptors leads to improved learning and/or memory performance in mice with spontaneous age-associated deficits.",

keywords = "Aging, Amnesia, Autoimmunity, Avoidance learning, Benzodiazepine receptor antagonist, C57BL/6NNia mice, Cognitive decline, Flumazenil, Memory, NZB/B1NJ mice",

author = "Harbans Lal and Forster, {Michael J.}",

note = "Funding Information: ACKNOWLEDGEMENTS This work was supported by NIH grants AG06182 (M.J.F.) and RR05879 (Texas College of Osteopathic Medicine). We thank Dr. Bala Kumar for his expert assistance and Hoffmann-LaR oche (Nutley, NJ) for their generous donation of flumazenil. Preliminary data leading to this report were presented previously in abstract form (12).",

year = "1990",

month = mar,

doi = "10.1016/0091-3057(90)90319-D",

language = "English",

volume = "35",

pages = "747--750",

journal = "Pharmacology, Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Flumazenil improves active avoidance performance in aging NZB/B1NJ and C57BL/6NNia mice

AU - Lal, Harbans

AU - Forster, Michael J.

N1 - Funding Information: ACKNOWLEDGEMENTS This work was supported by NIH grants AG06182 (M.J.F.) and RR05879 (Texas College of Osteopathic Medicine). We thank Dr. Bala Kumar for his expert assistance and Hoffmann-LaR oche (Nutley, NJ) for their generous donation of flumazenil. Preliminary data leading to this report were presented previously in abstract form (12).

PY - 1990/3

Y1 - 1990/3

N2 - C57BL/6NNia and autoimmune NZB/B1NJ mice aged 12-14 months were tested for acquisition and retention of an active avoidance response following vehicle or flumazenil (40 mg/kg), a benzodiazepine antagonist. Acquisition and retention performance was improved in flumazenil-treated mice when compared with vehicle-treated mice, although the degree of improvement varied with the level of performance in vehicle-treated mice of each strain. The NZB/B1NJ mice, which generally performed more poorly than the C57BL/6NNia mice, showed the greater improvements following flumazenil. These results suggest that antagonism of benzodiazepine receptors leads to improved learning and/or memory performance in mice with spontaneous age-associated deficits.

AB - C57BL/6NNia and autoimmune NZB/B1NJ mice aged 12-14 months were tested for acquisition and retention of an active avoidance response following vehicle or flumazenil (40 mg/kg), a benzodiazepine antagonist. Acquisition and retention performance was improved in flumazenil-treated mice when compared with vehicle-treated mice, although the degree of improvement varied with the level of performance in vehicle-treated mice of each strain. The NZB/B1NJ mice, which generally performed more poorly than the C57BL/6NNia mice, showed the greater improvements following flumazenil. These results suggest that antagonism of benzodiazepine receptors leads to improved learning and/or memory performance in mice with spontaneous age-associated deficits.

KW - Aging

KW - Amnesia

KW - Autoimmunity

KW - Avoidance learning

KW - Benzodiazepine receptor antagonist

KW - C57BL/6NNia mice

KW - Cognitive decline

KW - Flumazenil

KW - Memory

KW - NZB/B1NJ mice

UR - http://www.scopus.com/inward/record.url?scp=0025214125&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(90)90319-D

DO - 10.1016/0091-3057(90)90319-D

M3 - Article

C2 - 2160089

AN - SCOPUS:0025214125

VL - 35

SP - 747

EP - 750

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -

Flumazenil improves active avoidance performance in aging NZB/B1NJ and C57BL/6NNia mice

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this