Flumazenil improves active avoidance performance in aging NZB/B1NJ and C57BL/6NNia mice

Harbans Lal, Michael J. Forster

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

C57BL/6NNia and autoimmune NZB/B1NJ mice aged 12-14 months were tested for acquisition and retention of an active avoidance response following vehicle or flumazenil (40 mg/kg), a benzodiazepine antagonist. Acquisition and retention performance was improved in flumazenil-treated mice when compared with vehicle-treated mice, although the degree of improvement varied with the level of performance in vehicle-treated mice of each strain. The NZB/B1NJ mice, which generally performed more poorly than the C57BL/6NNia mice, showed the greater improvements following flumazenil. These results suggest that antagonism of benzodiazepine receptors leads to improved learning and/or memory performance in mice with spontaneous age-associated deficits.

Original languageEnglish
Pages (from-to)747-750
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume35
Issue number3
DOIs
StatePublished - Mar 1990

Keywords

  • Aging
  • Amnesia
  • Autoimmunity
  • Avoidance learning
  • Benzodiazepine receptor antagonist
  • C57BL/6NNia mice
  • Cognitive decline
  • Flumazenil
  • Memory
  • NZB/B1NJ mice

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