FK228 from Burkholderia thailandensis MSMB43

Xiang Yang Liu, Cheng Wang, Yi Qiang Cheng

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

FK228 [systematic name: (1S,4S,7Z,10S,16E,21R)-7-ethyl-idene-4,21- di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetra-za - bicyclo[8.7.6]tricos-16- ene-3,6,9,19,22-pentone], C24H36N4O 6S2, also known as FR901228, depsipeptide, NSC 630176, romidepsin, and marketed as Istodax by Celgene Corporation, is crystallized from ethyl acetate in P21 as compared to the absolute configuration of FK228, first crystallized from methanol in P21212 1 [Shigematsu et al. (1994). J. Anti-biot. 47, 311-314]. A slight difference is observed between the absolute configuration of FK228 and the present structure. The molecular structure is stabilized by intramolecular N - H⋯O hydrogen bonds. In the crystal, molecules are linked via N - H⋯O hydrogen bonds.

Original languageEnglish
Pages (from-to)o2757-o2758
JournalActa Crystallographica Section E: Structure Reports Online
Volume68
Issue number9
DOIs
StatePublished - Sep 2012

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