TY - JOUR
T1 - FK228 from Burkholderia thailandensis MSMB43
AU - Liu, Xiang Yang
AU - Wang, Cheng
AU - Cheng, Yi Qiang
PY - 2012/9
Y1 - 2012/9
N2 - FK228 [systematic name: (1S,4S,7Z,10S,16E,21R)-7-ethyl-idene-4,21- di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetra-za - bicyclo[8.7.6]tricos-16- ene-3,6,9,19,22-pentone], C24H36N4O 6S2, also known as FR901228, depsipeptide, NSC 630176, romidepsin, and marketed as Istodax by Celgene Corporation, is crystallized from ethyl acetate in P21 as compared to the absolute configuration of FK228, first crystallized from methanol in P21212 1 [Shigematsu et al. (1994). J. Anti-biot. 47, 311-314]. A slight difference is observed between the absolute configuration of FK228 and the present structure. The molecular structure is stabilized by intramolecular N - H⋯O hydrogen bonds. In the crystal, molecules are linked via N - H⋯O hydrogen bonds.
AB - FK228 [systematic name: (1S,4S,7Z,10S,16E,21R)-7-ethyl-idene-4,21- di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetra-za - bicyclo[8.7.6]tricos-16- ene-3,6,9,19,22-pentone], C24H36N4O 6S2, also known as FR901228, depsipeptide, NSC 630176, romidepsin, and marketed as Istodax by Celgene Corporation, is crystallized from ethyl acetate in P21 as compared to the absolute configuration of FK228, first crystallized from methanol in P21212 1 [Shigematsu et al. (1994). J. Anti-biot. 47, 311-314]. A slight difference is observed between the absolute configuration of FK228 and the present structure. The molecular structure is stabilized by intramolecular N - H⋯O hydrogen bonds. In the crystal, molecules are linked via N - H⋯O hydrogen bonds.
UR - http://www.scopus.com/inward/record.url?scp=84865704924&partnerID=8YFLogxK
U2 - 10.1107/S160053681203601X
DO - 10.1107/S160053681203601X
M3 - Article
C2 - 22969639
AN - SCOPUS:84865704924
SN - 1600-5368
VL - 68
SP - o2757-o2758
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
IS - 9
ER -