Children with special health care needs (CSHCN) generally use more health care and related services than do typically developing children, which increases the financial burden placed on the parents. The aim of this study is to use nationally representative data to explore the factors of financial stress across income levels of CSHCN. For this study the variables utilized were chosen from the stressors, resources, and support components. Multiple logistic regression was used to analyze the relationship between financial stress and the covariates of interest. We found that in all income categories, having a child with autism increased the odds of having financial stress. Our results suggest that the identified factors of financial stress differ according to the income of the families of CSHCN. Changes to health care systems and public policy particularly eligibility rules and benefit packages can potentially help reduce stress and decrease the number of CSHCN.