Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration

Robert F. Mullins, Marissa A. Olvera, Abbot F. Clark, Edwin M. Stone

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Fibulin-5 is an extracellular matrix glycoprotein that participates in elastogenesis. Mutations in the gene for fibulin-5 have been found to be associated with age-related macular degeneration. Little is known, however, about the expression of this gene in normal eyes or eyes with age-related macular degeneration. In this study, we evaluated the expression of the fibulin-5 protein in human donor eyes and localized this protein to Bruch's membrane and the intercapillary pillars of the choriocapillaris in normal eyes. In eyes with age-related macular degeneration, fibulin-5 was localized to pathologic basal deposits beneath the retinal pigment epithelium as well as some small drusen. These results suggest that fibulin-5 may promote extracellular deposit formation in macular degeneration.

Original languageEnglish
Pages (from-to)378-380
Number of pages3
JournalExperimental eye research
Volume84
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Bruch's membrane
  • age-related macular degeneration
  • extracellular matrix
  • fibulins

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