Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration

Robert F. Mullins; Marissa A. Olvera; Abbot F. Clark; Edwin M. Stone

doi:10.1016/j.exer.2006.09.021

Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration

Robert F. Mullins, Marissa A. Olvera, Abbot F. Clark, Edwin M. Stone

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Fibulin-5 is an extracellular matrix glycoprotein that participates in elastogenesis. Mutations in the gene for fibulin-5 have been found to be associated with age-related macular degeneration. Little is known, however, about the expression of this gene in normal eyes or eyes with age-related macular degeneration. In this study, we evaluated the expression of the fibulin-5 protein in human donor eyes and localized this protein to Bruch's membrane and the intercapillary pillars of the choriocapillaris in normal eyes. In eyes with age-related macular degeneration, fibulin-5 was localized to pathologic basal deposits beneath the retinal pigment epithelium as well as some small drusen. These results suggest that fibulin-5 may promote extracellular deposit formation in macular degeneration.

Original language	English
Pages (from-to)	378-380
Number of pages	3
Journal	Experimental eye research
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/j.exer.2006.09.021
State	Published - Feb 2007

Keywords

Bruch's membrane
age-related macular degeneration
extracellular matrix
fibulins

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title = "Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration",

abstract = "Fibulin-5 is an extracellular matrix glycoprotein that participates in elastogenesis. Mutations in the gene for fibulin-5 have been found to be associated with age-related macular degeneration. Little is known, however, about the expression of this gene in normal eyes or eyes with age-related macular degeneration. In this study, we evaluated the expression of the fibulin-5 protein in human donor eyes and localized this protein to Bruch's membrane and the intercapillary pillars of the choriocapillaris in normal eyes. In eyes with age-related macular degeneration, fibulin-5 was localized to pathologic basal deposits beneath the retinal pigment epithelium as well as some small drusen. These results suggest that fibulin-5 may promote extracellular deposit formation in macular degeneration.",

keywords = "Bruch's membrane, age-related macular degeneration, extracellular matrix, fibulins",

author = "Mullins, {Robert F.} and Olvera, {Marissa A.} and Clark, {Abbot F.} and Stone, {Edwin M.}",

note = "Funding Information: Funded in part by the Howard Hughes Medical Institute (EMS), NEI grant EY-014563 (RFM), NEI Grant EY-016822 (EMS), and a center grant from the Foundation Fighting Blindness. ",

year = "2007",

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doi = "10.1016/j.exer.2006.09.021",

language = "English",

volume = "84",

pages = "378--380",

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T2 - Relevance to age-related macular degeneration

AU - Mullins, Robert F.

AU - Olvera, Marissa A.

AU - Clark, Abbot F.

AU - Stone, Edwin M.

N1 - Funding Information: Funded in part by the Howard Hughes Medical Institute (EMS), NEI grant EY-014563 (RFM), NEI Grant EY-016822 (EMS), and a center grant from the Foundation Fighting Blindness.

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N2 - Fibulin-5 is an extracellular matrix glycoprotein that participates in elastogenesis. Mutations in the gene for fibulin-5 have been found to be associated with age-related macular degeneration. Little is known, however, about the expression of this gene in normal eyes or eyes with age-related macular degeneration. In this study, we evaluated the expression of the fibulin-5 protein in human donor eyes and localized this protein to Bruch's membrane and the intercapillary pillars of the choriocapillaris in normal eyes. In eyes with age-related macular degeneration, fibulin-5 was localized to pathologic basal deposits beneath the retinal pigment epithelium as well as some small drusen. These results suggest that fibulin-5 may promote extracellular deposit formation in macular degeneration.

AB - Fibulin-5 is an extracellular matrix glycoprotein that participates in elastogenesis. Mutations in the gene for fibulin-5 have been found to be associated with age-related macular degeneration. Little is known, however, about the expression of this gene in normal eyes or eyes with age-related macular degeneration. In this study, we evaluated the expression of the fibulin-5 protein in human donor eyes and localized this protein to Bruch's membrane and the intercapillary pillars of the choriocapillaris in normal eyes. In eyes with age-related macular degeneration, fibulin-5 was localized to pathologic basal deposits beneath the retinal pigment epithelium as well as some small drusen. These results suggest that fibulin-5 may promote extracellular deposit formation in macular degeneration.

KW - Bruch's membrane

KW - age-related macular degeneration

KW - extracellular matrix

KW - fibulins

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JO - Experimental Eye Research

JF - Experimental Eye Research

SN - 0014-4835

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ER -

Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration

Abstract

Keywords

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