Fatty Acid-Binding Protein 3 Is a Marker of Neurodegeneration and White Matter Hyperintensity Burden in Mexican American Older Adults

Health and Aging Brain Study – Health Disparities (HABS-HD) Study Team

Research output: Contribution to journalLetterpeer-review

1 Scopus citations

Abstract

We examined ethnoracial differences in fatty acid binding protein (FABP)-a family of intracellular lipid carriers-and clarified FABP3 associations with gray and white matter. Relative to Mexican Americans (MAs), FABP3 was higher in Non-Hispanic Whites (NHWS, p < 0.001). Regressions revealed, independent of traditional AD markers, FABP3 was associated with neurodegeneration (B = -0.08, p = 0.003) and WMH burden (B = 0.18, p = 0.03) in MAs, but not in NHWs (ps > 0.18). Findings suggest FABP3 is related to neural health within MAs and highlight its potential as a prognostic marker of brain health in ethnoracially diverse older adults.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalJournal of Alzheimer's disease : JAD
Volume90
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Alzheimer’s disease
  • FABP3
  • Hispanic/Latino
  • lipid dyshomeostasis
  • mild cognitive impairment

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