Abstract
We examined ethnoracial differences in fatty acid binding protein (FABP)-a family of intracellular lipid carriers-and clarified FABP3 associations with gray and white matter. Relative to Mexican Americans (MAs), FABP3 was higher in Non-Hispanic Whites (NHWS, p < 0.001). Regressions revealed, independent of traditional AD markers, FABP3 was associated with neurodegeneration (B = -0.08, p = 0.003) and WMH burden (B = 0.18, p = 0.03) in MAs, but not in NHWs (ps > 0.18). Findings suggest FABP3 is related to neural health within MAs and highlight its potential as a prognostic marker of brain health in ethnoracially diverse older adults.
Original language | English |
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Pages (from-to) | 61-68 |
Number of pages | 8 |
Journal | Journal of Alzheimer's disease : JAD |
Volume | 90 |
Issue number | 1 |
DOIs | |
State | Published - 2022 |
Keywords
- Alzheimer’s disease
- FABP3
- Hispanic/Latino
- lipid dyshomeostasis
- mild cognitive impairment