Fat stem cells

Jeffrey M. Gimble, Bruce A. Bunnell, Farshid Guilak

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Adipose tissue is an abundant, accessible, and replenishable source of adult stem cells. Adipose-derived stem cells (ASCs) can be isolated from human lipoaspirates by collagenase digestion, differential centrifugation, and plastic adherence. The ASCs display a consistent immunophenotype that is similar, but not identical, to that of bone marrow-derived mesenchymal stem cells (BMSCs). Like BMSCs, ASCs inhibit mixed lymphocyte reactions in vitro, suggesting that it will be possible to perform allogeneic transplants in clinical settings. The expanded ASCs are multipotent and can differentiate into adipocytes, chondrocytes, endothelial cells, myocytes, neuronal-like cells, and osteoblasts, among other lineages. Furthermore, genetic engineering methods can be applied to ASCs, allowing their potential use as gene delivery vehicles in vivo. This chapter reviews the expanding literature base relating to ASC applications for regenerative medicine.

Original languageEnglish
Title of host publicationAdvances in Tissue Engineering
PublisherImperial College Press
Pages143-174
Number of pages32
ISBN (Electronic)9781848161832
ISBN (Print)9781848161825
DOIs
StatePublished - 1 Jan 2008

Keywords

  • Adipose-Derived Stem Cells (ASCs)
  • Cytokine Profile
  • Differentiation
  • Immunogenicity
  • Immunophenotype

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    Gimble, J. M., Bunnell, B. A., & Guilak, F. (2008). Fat stem cells. In Advances in Tissue Engineering (pp. 143-174). Imperial College Press. https://doi.org/10.1142/9781848161832_0008