TY - JOUR
T1 - Failure of ritanserin to block the discriminative or reinforcing stimulus effects of cocaine
AU - Peltier, R. L.
AU - Emmett-Oglesby, M. W.
AU - Thomas, W. H.
AU - Schenk, S.
PY - 1994/6
Y1 - 1994/6
N2 - Ritanserin, a 5-HT 2 1c antagonist, has been suggested to reduce the preference for cocaine in rats. In the present experiment, the action of ritanserin was investigated in locomotor activity, cocaine drug discrimination, and cocaine self-administration paradigms in rats. A low dose of ritanserin (1.0 mg/kg) was without effect on locomotor activity, while a higher dose (10.0 mg/kg) reduced both horizontal and vertical locomotor activity counts during the first 30 min of the test session. Ritanserin (0.32-32 mg/kg) did not significantly affect the discrimination of 10 mg/kg of cocaine, nor did a dose of 10.0 mg/kg significantly modify the dose-effect curve for cocaine discrimination. Ritanserin (1.0 and 10.0 mg/kg) had no significant effect on the dose-response curve for cocaine self-administration. Thus, ritanserin was without effect against either the discriminative or reinforcing stimulus effects of cocaine, suggesting that ritanserin has limited efficacy as a potential treatment for cocaine abuse.
AB - Ritanserin, a 5-HT 2 1c antagonist, has been suggested to reduce the preference for cocaine in rats. In the present experiment, the action of ritanserin was investigated in locomotor activity, cocaine drug discrimination, and cocaine self-administration paradigms in rats. A low dose of ritanserin (1.0 mg/kg) was without effect on locomotor activity, while a higher dose (10.0 mg/kg) reduced both horizontal and vertical locomotor activity counts during the first 30 min of the test session. Ritanserin (0.32-32 mg/kg) did not significantly affect the discrimination of 10 mg/kg of cocaine, nor did a dose of 10.0 mg/kg significantly modify the dose-effect curve for cocaine discrimination. Ritanserin (1.0 and 10.0 mg/kg) had no significant effect on the dose-response curve for cocaine self-administration. Thus, ritanserin was without effect against either the discriminative or reinforcing stimulus effects of cocaine, suggesting that ritanserin has limited efficacy as a potential treatment for cocaine abuse.
KW - Cocaine
KW - Drug discrimination
KW - Locomotor activity
KW - Ritanserin
KW - Self-administration
UR - http://www.scopus.com/inward/record.url?scp=0028308534&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(94)90555-X
DO - 10.1016/0091-3057(94)90555-X
M3 - Article
C2 - 8090817
AN - SCOPUS:0028308534
SN - 0091-3057
VL - 48
SP - 473
EP - 478
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -