TY - JOUR
T1 - Factors associated with human papillomavirus (HPV) test acceptability in primary screening for cervical cancer
T2 - A mixed methods research synthesis
AU - Tatar, Ovidiu
AU - Thompson, Erika
AU - Naz, Anila
AU - Perez, Samara
AU - Shapiro, Gilla K.
AU - Wade, Kristina
AU - Zimet, Gregory
AU - Gilca, Vladimir
AU - Janda, Monika
AU - Kahn, Jessica
AU - Daley, Ellen
AU - Rosberger, Zeev
N1 - Funding Information:
This work was supported by a grant from the Canadian Cancer Society Research Institute (CCSRI, Grant # 704036 ). GS is a Vanier CIHR Canada Graduate Scholar and Queen Elizabeth II Diamond Jubilee Scholar. SP is a Vanier CIHR Canada Graduate Scholar.
Funding Information:
Zeev Rosberger reports personal fees from Merck outside the submitted work at a consultation meeting in November 2015; and speaker to family physicians in April 2015. Gregory Zimet reports grants from Merck, grants from Roche, personal fees from Merck, outside the submitted work.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/11
Y1 - 2018/11
N2 - Primary screening for cervical cancer is transitioning from the longstanding Pap smear towards implementation of an HPV-DNA test, which is more sensitive than Pap cytology in detecting high-risk lesions and offers greater protection against invasive cervical carcinomas. Based on these results, many countries are recommending and implementing HPV testing-based screening programs. Understanding what factors (e.g., knowledge, attitudes) will impact on HPV test acceptability by women is crucial for ensuring adequate public health practices to optimize cervical screening uptake. We used mixed methods research synthesis to provide a categorization of the relevant factors related to HPV primary screening for cervical cancer and describe their influence on women's acceptability of HPV testing. We searched Medline, Embase, PsycINFO, CINAHL, Global Health and Web of Science for journal articles between January 1, 1980 and October 31, 2017 and retained 22 empirical articles. Our results show that while most factors associated with HPV test acceptability are included in the Health Belief Model and/or Theory of Planned Behavior (e.g., attitudes, knowledge), other important factors are not encompassed by these theoretical frameworks (e.g., health behaviors, negative emotional reactions related to HPV testing). The direction of influence of psychosocial factors on HPV test acceptability was synthesized based on 14 quantitative studies as: facilitators (e.g., high perceived HPV test benefits), barriers (e.g., negative attitudes towards increased screening intervals), contradictory evidence (e.g., sexual history) and no impact (e.g., high perceived severity of HPV infection). Further population-based studies are needed to confirm the impact of these factors on HPV-based screening acceptability.
AB - Primary screening for cervical cancer is transitioning from the longstanding Pap smear towards implementation of an HPV-DNA test, which is more sensitive than Pap cytology in detecting high-risk lesions and offers greater protection against invasive cervical carcinomas. Based on these results, many countries are recommending and implementing HPV testing-based screening programs. Understanding what factors (e.g., knowledge, attitudes) will impact on HPV test acceptability by women is crucial for ensuring adequate public health practices to optimize cervical screening uptake. We used mixed methods research synthesis to provide a categorization of the relevant factors related to HPV primary screening for cervical cancer and describe their influence on women's acceptability of HPV testing. We searched Medline, Embase, PsycINFO, CINAHL, Global Health and Web of Science for journal articles between January 1, 1980 and October 31, 2017 and retained 22 empirical articles. Our results show that while most factors associated with HPV test acceptability are included in the Health Belief Model and/or Theory of Planned Behavior (e.g., attitudes, knowledge), other important factors are not encompassed by these theoretical frameworks (e.g., health behaviors, negative emotional reactions related to HPV testing). The direction of influence of psychosocial factors on HPV test acceptability was synthesized based on 14 quantitative studies as: facilitators (e.g., high perceived HPV test benefits), barriers (e.g., negative attitudes towards increased screening intervals), contradictory evidence (e.g., sexual history) and no impact (e.g., high perceived severity of HPV infection). Further population-based studies are needed to confirm the impact of these factors on HPV-based screening acceptability.
KW - Barriers
KW - Facilitators
KW - Human Papillomavirus DNA Tests
KW - Human papillomavirus
KW - Mass Screening
KW - Mixed methods
KW - Psychology
KW - Psychosocial
KW - Review
KW - Uterine Cervical Neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85052727233&partnerID=8YFLogxK
U2 - 10.1016/j.ypmed.2018.08.034
DO - 10.1016/j.ypmed.2018.08.034
M3 - Review article
C2 - 30172799
AN - SCOPUS:85052727233
SN - 0091-7435
VL - 116
SP - 40
EP - 50
JO - Preventive Medicine
JF - Preventive Medicine
ER -