Factors affecting the esterification of lipoprotein cholesterol by lecithin: Cholesterol acyl transferase

Joshua S.K. David, Louis A. Soloff, Andras G. Lacko

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Lecithin: Cholesterol Acyltransferase (LCAT) esterified relatively small amounts of cholesterol from very low density lipoproteins (VLDL), low density lipoproteins (LDL) or high density lipoproteins (HDL) in the presence of 5% human serum albumin (HSA). On the other hand, in the presence of very high density (>1.225 g/ml) plasma fraction (F-4), the enzyme esterified cholesterol from VLDL at considerably higher rates than from LDL or HDL. VLDL together with some component present in the very high density plasma fraction (F-4) may thus provide a highly efficient complex resulting in a favorable configuration of substrate lipids for the enzyme.

Original languageEnglish
Pages (from-to)701-706
Number of pages6
JournalLife Sciences
Volume18
Issue number7
DOIs
StatePublished - 1 Apr 1976

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