Factors affecting the esterification of lipoprotein cholesterol by lecithin: Cholesterol acyl transferase

Joshua S.K. David, Louis A. Soloff, Andras G. Lacko

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lecithin: Cholesterol Acyltransferase (LCAT) esterified relatively small amounts of cholesterol from very low density lipoproteins (VLDL), low density lipoproteins (LDL) or high density lipoproteins (HDL) in the presence of 5% human serum albumin (HSA). On the other hand, in the presence of very high density (>1.225 g/ml) plasma fraction (F-4), the enzyme esterified cholesterol from VLDL at considerably higher rates than from LDL or HDL. VLDL together with some component present in the very high density plasma fraction (F-4) may thus provide a highly efficient complex resulting in a favorable configuration of substrate lipids for the enzyme.

Original languageEnglish
Pages (from-to)701-706
Number of pages6
JournalLife Sciences
Volume18
Issue number7
DOIs
StatePublished - 1 Apr 1976

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VLDL Cholesterol
Lecithins
Esterification
HDL Lipoproteins
Transferases
LDL Lipoproteins
Cholesterol
Phosphatidylcholine-Sterol O-Acyltransferase
VLDL Lipoproteins
Plasma density
Enzymes
Serum Albumin
Lipids
Plasmas
Substrates
lipoprotein cholesterol
F 4

Cite this

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abstract = "Lecithin: Cholesterol Acyltransferase (LCAT) esterified relatively small amounts of cholesterol from very low density lipoproteins (VLDL), low density lipoproteins (LDL) or high density lipoproteins (HDL) in the presence of 5{\%} human serum albumin (HSA). On the other hand, in the presence of very high density (>1.225 g/ml) plasma fraction (F-4), the enzyme esterified cholesterol from VLDL at considerably higher rates than from LDL or HDL. VLDL together with some component present in the very high density plasma fraction (F-4) may thus provide a highly efficient complex resulting in a favorable configuration of substrate lipids for the enzyme.",
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Factors affecting the esterification of lipoprotein cholesterol by lecithin : Cholesterol acyl transferase. / David, Joshua S.K.; Soloff, Louis A.; Lacko, Andras G.

In: Life Sciences, Vol. 18, No. 7, 01.04.1976, p. 701-706.

Research output: Contribution to journalArticle

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T1 - Factors affecting the esterification of lipoprotein cholesterol by lecithin

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AU - Soloff, Louis A.

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