Abstract
Endothelin is an endogenous vasoactive peptide that is considered among the most potent vasoconstrictor substances known. In addition to its vascular effects, endothelins and their receptors have been shown to be present in the eye and to have a number of ocular actions that may be important for ocular homeostasis, but, in excess can be a potential contributor to ocular neuropathy in glaucoma. The current review focuses on the cellular and molecular aspects of endothelins and its receptors in the eye with an emphasis on its relationship to ocular function and its potential role in the etiology of glaucoma pathophysiology.
| Original language | English |
|---|---|
| Pages (from-to) | 71-88 |
| Number of pages | 18 |
| Journal | Molecular and Cellular Biochemistry |
| Volume | 253 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 1 Nov 2003 |
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Keywords
- ET receptors
- ET signaling
- Endothelin
- Glaucoma
Cite this
}
Eyeing endothelins : A cellular perspective. / Prasanna, Ganesh; Narayan, Santosh; Krishnamoorthy, Raghu; Yorio, Thomas.
In: Molecular and Cellular Biochemistry, Vol. 253, No. 1-2, 01.11.2003, p. 71-88.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Eyeing endothelins
T2 - A cellular perspective
AU - Prasanna, Ganesh
AU - Narayan, Santosh
AU - Krishnamoorthy, Raghu
AU - Yorio, Thomas
PY - 2003/11/1
Y1 - 2003/11/1
N2 - Endothelin is an endogenous vasoactive peptide that is considered among the most potent vasoconstrictor substances known. In addition to its vascular effects, endothelins and their receptors have been shown to be present in the eye and to have a number of ocular actions that may be important for ocular homeostasis, but, in excess can be a potential contributor to ocular neuropathy in glaucoma. The current review focuses on the cellular and molecular aspects of endothelins and its receptors in the eye with an emphasis on its relationship to ocular function and its potential role in the etiology of glaucoma pathophysiology.
AB - Endothelin is an endogenous vasoactive peptide that is considered among the most potent vasoconstrictor substances known. In addition to its vascular effects, endothelins and their receptors have been shown to be present in the eye and to have a number of ocular actions that may be important for ocular homeostasis, but, in excess can be a potential contributor to ocular neuropathy in glaucoma. The current review focuses on the cellular and molecular aspects of endothelins and its receptors in the eye with an emphasis on its relationship to ocular function and its potential role in the etiology of glaucoma pathophysiology.
KW - ET receptors
KW - ET signaling
KW - Endothelin
KW - Glaucoma
UR - http://www.scopus.com/inward/record.url?scp=0142243412&partnerID=8YFLogxK
U2 - 10.1023/A:1026005418874
DO - 10.1023/A:1026005418874
M3 - Review article
C2 - 14619958
AN - SCOPUS:0142243412
VL - 253
SP - 71
EP - 88
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
SN - 0300-8177
IS - 1-2
ER -