Eyeing endothelins: A cellular perspective

Ganesh Prasanna, Santosh Narayan, Raghu Krishnamoorthy, Thomas Yorio

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

Endothelin is an endogenous vasoactive peptide that is considered among the most potent vasoconstrictor substances known. In addition to its vascular effects, endothelins and their receptors have been shown to be present in the eye and to have a number of ocular actions that may be important for ocular homeostasis, but, in excess can be a potential contributor to ocular neuropathy in glaucoma. The current review focuses on the cellular and molecular aspects of endothelins and its receptors in the eye with an emphasis on its relationship to ocular function and its potential role in the etiology of glaucoma pathophysiology.

Original languageEnglish
Pages (from-to)71-88
Number of pages18
JournalMolecular and Cellular Biochemistry
Volume253
Issue number1-2
DOIs
StatePublished - 1 Nov 2003

Keywords

  • ET receptors
  • ET signaling
  • Endothelin
  • Glaucoma

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