Expression of mutant myocilin induces abnormal intracellular accumulation of selected extracellular matrix proteins in the trabecular meshwork

Keyphrases

• Trabecular Meshwork 100%
• Extracellular Matrix Protein 1 (ECM1) 100%
• Myocilin 100%
• Intracellular Accumulation 100%
• Trabecular Meshwork Cells 57%
• Outflow Facility 35%
• Endoplasmic Reticulum Stress (ER stress) 21%
• Fibronectin 21%
• Endoplasmic Reticulum 21%
• IOP Elevation 21%
• Littermate 21%
• Extracellular Matrix Accumulation 14%
• Immunostaining 14%
• Human Trabecular Meshwork 14%
• Collagen I 14%
• Stably Expressing 14%
• Elastin 14%
• Sodium 4-phenylbutyrate 7%
• Glaucoma 7%
• Protein Level 7%
• Western Blot 7%
• Western Blotting 7%
• Stress Markers 7%
• Extracellular Matrix 7%
• Aqueous Humor Outflow 7%
• Quantitative PCR 7%
• Conditioned Medium 7%
• Transgenic Mouse Model 7%
• Rebound Tonometer 7%
• Matrix metalloproteinase-2 (MMP-2) 7%
• Matrix metalloproteinase-9 (MMP-9) 7%
• Collagen IV 7%
• Glucose-regulated Protein 78 (GRP78) 7%
• Genetic Causes 7%
• 4-phenylbutyrate 7%
• Collagen Type IV 7%
• Collagen Type I 7%
• Laminin 7%
• Intracellular Protein 7%
• Active Form 7%
• DsRed 7%

Biochemistry, Genetics and Molecular Biology

• Extracellular Matrix Proteins 100%
• Scleroprotein 100%
• Wild Type 100%
• Endoplasmic Reticulum Stress 50%
• Fibronectin 50%
• Immunostaining 33%
• Western Blotting 33%
• Elastin 33%
• Secretion (Process) 16%
• Genetics 16%
• Mouse Model 16%
• Aqueous Humor Outflow 16%
• Real-Time Polymerase Chain Reaction 16%
• Transgenic Mouse 16%
• Rebound 16%
• Laminin 16%
• Gelatinase B 16%
• MMP9 16%
• Gelatinase A 16%
• MMP2 16%
• Type I Collagen 16%
• Type IV Collagen 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Scleroprotein 100%
• Myocilin 100%
• Fibronectin 21%
• Sodium Phenylbutyrate 14%
• Western Blot 14%
• Elastin 14%
• Glaucoma 7%
• Mouse Model 7%
• Collagen Type 1 7%
• Transgenic Mouse 7%
• Cell Protein 7%
• Gelatinase A 7%
• Gelatinase B 7%
• Collagen Type 4 7%
• Laminin 7%