Expression of ICAM-1 in implanted primary and metastatic squamous cell carcinomas in rats

Xinwei Li, Yoshihisa Fujikura, Yu Hsueh Wang, Tomoo Sawada, Nobuko Tokuda, Rehana Sultana Lovely, Yoshikazu Hayatsu, Tetsuo Fukumoto, Fumihiko Shinozaki

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Abstract

F6 tumor cells are derived from a spontaneous rat squamous cell carcinoma (SCC) which originally arose in the facial skin of a DA rat. In this study, FF6 tumor cells were implanted into rat oral mucosa to establish an ex vivo metastatic model. We analyzed the expression of intercellular cell adhesion molecule-1 (ICAM-1) in the implanted primary and metastatic FF6 tumors by immunostaining with a monoclonal antibody (mAb) against ICAM-1. The implanted primary FF6 cells showed strong expression of ICAM-1, whereas the tumor cells of metastatic lesions showed weak or negative expression of ICAM-1. By immunostaining with mAb OX6, a number of MHC class II-positive macrophages were detected in tumor mesenchyme and surrounding the metastatic foci. These results suggested that the local immune reaction in the lymph node influenced the expression of ICAM-1 on tumor cells, and that MHC class II-positive macrophages may play a role in transplanted tumor growth and metastases.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume26
Issue number8
DOIs
StatePublished - Sep 1997

Keywords

  • FF6
  • Intercellular cell adhesion molecule-1 (ICAM-1)
  • Metastasis
  • Squamous cell carcinoma (SCC)

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    Li, X., Fujikura, Y., Wang, Y. H., Sawada, T., Tokuda, N., Lovely, R. S., Hayatsu, Y., Fukumoto, T., & Shinozaki, F. (1997). Expression of ICAM-1 in implanted primary and metastatic squamous cell carcinomas in rats. Journal of Oral Pathology and Medicine, 26(8), 371-376. https://doi.org/10.1111/j.1600-0714.1997.tb00233.x