Expression of ICAM-1 in implanted primary and metastatic squamous cell carcinomas in rats

Xinwei Li, Yoshihisa Fujikura, Yu Hsueh Wang, Tomoo Sawada, Nobuko Tokuda, Rehana Sultana Lovely, Yoshikazu Hayatsu, Tetsuo Fukumoto, Fumihiko Shinozaki

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


F6 tumor cells are derived from a spontaneous rat squamous cell carcinoma (SCC) which originally arose in the facial skin of a DA rat. In this study, FF6 tumor cells were implanted into rat oral mucosa to establish an ex vivo metastatic model. We analyzed the expression of intercellular cell adhesion molecule-1 (ICAM-1) in the implanted primary and metastatic FF6 tumors by immunostaining with a monoclonal antibody (mAb) against ICAM-1. The implanted primary FF6 cells showed strong expression of ICAM-1, whereas the tumor cells of metastatic lesions showed weak or negative expression of ICAM-1. By immunostaining with mAb OX6, a number of MHC class II-positive macrophages were detected in tumor mesenchyme and surrounding the metastatic foci. These results suggested that the local immune reaction in the lymph node influenced the expression of ICAM-1 on tumor cells, and that MHC class II-positive macrophages may play a role in transplanted tumor growth and metastases.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalJournal of Oral Pathology and Medicine
Issue number8
StatePublished - Sep 1997


  • FF6
  • Intercellular cell adhesion molecule-1 (ICAM-1)
  • Metastasis
  • Squamous cell carcinoma (SCC)


Dive into the research topics of 'Expression of ICAM-1 in implanted primary and metastatic squamous cell carcinomas in rats'. Together they form a unique fingerprint.

Cite this