Explosive mutation accumulation triggered by heterozygous human Pol ɛ proofreading-deficiency is driven by suppression of mismatch repair

Keyphrases

• Polymerase Proofreading 100%
• Mismatch Repair 100%
• Explosives 100%
• Mutation Accumulation 100%
• Tumor 60%
• Mutagenesis 40%
• Next-generation Sequencing 20%
• Unanswered Questions 20%
• Polymerase 20%
• Aggressive Tumor 20%
• Biallelic Mismatch Repair Deficiency 20%
• In Vitro Biochemistry 20%
• Polymerase mutants 20%
• Unique mutation 20%
• Monoallelic 20%
• Exonuclease 20%
• Mutation Signature 20%
• DNA Polymerase Proofreading 20%
• Blood Tumor mutational Burden 20%
• Human Cell Lines 20%

Biochemistry, Genetics and Molecular Biology

• Polymerase 100%
• Mutation Accumulation 100%
• DNA Mismatch Repair 100%
• Mutagenesis 33%
• Biochemistry 16%
• DNA Polymerase 16%
• Next Generation Sequencing 16%
• Exonuclease 16%