Exploratory pharmacokinetics and brain distribution study of a neuropeptide FF antagonist by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry

Keyphrases

• Neuropeptide FF 100%
• Pharmacokinetics 100%
• Tandem Mass Spectrometry 100%
• Liquid Chromatography 100%
• Atmospheric Pressure Ionization 100%
• Brain Distribution 100%
• Dansyl 66%
• Brain Tissue 33%
• Pharmacokinetic Profile 33%
• Brain Concentration 33%
• Experimental Animals 33%
• Limit of Detection 33%
• Reversed-phase HPLC 33%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 33%
• Collision-induced Dissociation 33%
• Intravenous Administration 33%
• Choice Method 33%
• Assay Method 33%
• Amides 33%
• Solid-phase Extraction 33%
• Tripeptide 33%
• Quadrupole Ion Trap 33%
• Matrix Interference 33%
• Fragment Ions 33%
• CNS Bioavailability 33%
• Protonated Molecules 33%
• Solid Phase Preconcentration 33%
• Narrow Bore 33%
• Positive Ions 33%
• Rapid Sample Preparation 33%

Chemistry

• Pharmacokinetics 100%
• Liquid Chromatography 100%
• Tandem Mass Spectrometry 100%
• Neuropeptide FF 100%
• Electrospray Ionization 66%
• Pro-Gln 66%
• Arginine 66%
• Reverse Phase Liquid Chromatography 33%
• Collisionally Activated Dissociation (CAD) 33%
• Collision Induced Dissociation 33%
• Positive Ion 33%
• Quadrupole 33%
• Ion Trap 33%
• Carboxamide 33%
• Atmospheric Pressure Chemical Ionization 33%
• Bioavailability 33%
• Solid-Phase Extraction 33%
• Preconcentration 33%
• Tripeptide 33%

Immunology and Microbiology

• Pharmacokinetics 100%
• Blood Plasma 100%
• Electrospray Ionization 100%
• Tandem Mass Spectrometry 100%
• Liquid Chromatography 100%
• Atmospheric Pressure 100%
• Brain Tissue 50%
• Experimental Animal 50%
• Solid Phase Extraction 50%
• Collisionally Activated Dissociation 50%