Experimental studies on some aspects of toxicological effects of gas phase cigarette smoke (GPCS)

L. J. Yan; B. L. Zhao; W. J. Xin

doi:10.1163/156856791X00156

Experimental studies on some aspects of toxicological effects of gas phase cigarette smoke (GPCS)

L. J. Yan, B. L. Zhao, W. J. Xin

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We have studied the toxicological effects of gas phase cigarette smoke (GPCS) on: 1) lecithin-formed liposome lipid peroxidation; 2) the liposomal membrane fluidity; 3) conformation changes of rat lung cell membrane proteins; and 4) respiratory burst of human polymorphonuclear leukocytes. The results of these investigations suggested that by stimulating lipid peroxidation, GPCS can cause changes of membrane fluidity and alterations of membrane protein conformations as well as damages to membrane-bound enzymes. We conclude that oxidative damage to cells and tissues is an important toxicological property of GPCS.

Original language	English
Pages (from-to)	15-28
Number of pages	14
Journal	Research on Chemical Intermediates
Volume	16
Issue number	1
DOIs	https://doi.org/10.1163/156856791X00156
State	Published - Mar 1991

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title = "Experimental studies on some aspects of toxicological effects of gas phase cigarette smoke (GPCS)",

abstract = "We have studied the toxicological effects of gas phase cigarette smoke (GPCS) on: 1) lecithin-formed liposome lipid peroxidation; 2) the liposomal membrane fluidity; 3) conformation changes of rat lung cell membrane proteins; and 4) respiratory burst of human polymorphonuclear leukocytes. The results of these investigations suggested that by stimulating lipid peroxidation, GPCS can cause changes of membrane fluidity and alterations of membrane protein conformations as well as damages to membrane-bound enzymes. We conclude that oxidative damage to cells and tissues is an important toxicological property of GPCS.",

author = "Yan, {L. J.} and Zhao, {B. L.} and Xin, {W. J.}",

note = "Funding Information: This research was supported by the Natural Science Foundation of China. We to Mr. Jing-Wu Hou for getting blood for the work and to Ms. Xiao-Jie Li",

year = "1991",

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doi = "10.1163/156856791X00156",

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T1 - Experimental studies on some aspects of toxicological effects of gas phase cigarette smoke (GPCS)

AU - Yan, L. J.

AU - Zhao, B. L.

AU - Xin, W. J.

N1 - Funding Information: This research was supported by the Natural Science Foundation of China. We to Mr. Jing-Wu Hou for getting blood for the work and to Ms. Xiao-Jie Li

PY - 1991/3

Y1 - 1991/3

N2 - We have studied the toxicological effects of gas phase cigarette smoke (GPCS) on: 1) lecithin-formed liposome lipid peroxidation; 2) the liposomal membrane fluidity; 3) conformation changes of rat lung cell membrane proteins; and 4) respiratory burst of human polymorphonuclear leukocytes. The results of these investigations suggested that by stimulating lipid peroxidation, GPCS can cause changes of membrane fluidity and alterations of membrane protein conformations as well as damages to membrane-bound enzymes. We conclude that oxidative damage to cells and tissues is an important toxicological property of GPCS.

AB - We have studied the toxicological effects of gas phase cigarette smoke (GPCS) on: 1) lecithin-formed liposome lipid peroxidation; 2) the liposomal membrane fluidity; 3) conformation changes of rat lung cell membrane proteins; and 4) respiratory burst of human polymorphonuclear leukocytes. The results of these investigations suggested that by stimulating lipid peroxidation, GPCS can cause changes of membrane fluidity and alterations of membrane protein conformations as well as damages to membrane-bound enzymes. We conclude that oxidative damage to cells and tissues is an important toxicological property of GPCS.

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ER -

Experimental studies on some aspects of toxicological effects of gas phase cigarette smoke (GPCS)

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