Abstract
Hepatitis C virus (HCV) infects its target cells in the form of cell-free viruses and through cell-cell contact. Here we report that HCV is associated with exosomes. Using highly purified exosomes and transmission electron microscopic imaging, we demonstrated that HCV occurred in both exosome-free and exosome-associated forms. Exosome-associated HCV was infectious and resistant to neutralization by an anti-HCV neutralizing antibody. There were more exosome-associated HCV than exosome-free HCV detected in the plasma of HCV-infected patients. These results suggest exosome-associated HCV as an alternative form for HCV infection and transmission.
| Original language | English |
|---|---|
| Pages (from-to) | 218-222 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 455 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 12 Dec 2014 |
Keywords
- Exosome
- HCV
- Infection
- Neutralizing antibody
- Patient plasma
- TEM imaging
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Liu, Z., Zhang, X., Yu, Q., & He, J. J. (2014). Exosome-associated hepatitis C virus in cell cultures and patient plasma. Biochemical and Biophysical Research Communications, 455(3-4), 218-222. https://doi.org/10.1016/j.bbrc.2014.10.146