TY - JOUR
T1 - Exercise training improves hemodynamic recovery to isometric exercise in obese men with type 2 diabetes but not in obese women
AU - Kanaley, Jill A.
AU - Goulopoulou, Styliani
AU - Franklin, Ruth
AU - Baynard, Tracy
AU - Carhart, Robert L.
AU - Weinstock, Ruth S.
AU - Fernhall, Bo
N1 - Funding Information:
We thank Rose Kingsbury, RN, NP for her dedication to the study and placing all of the catheters. This project was supported by National Institute of Health (NIH) Grant R21DK063179 .
PY - 2012/12
Y1 - 2012/12
N2 - Objectives: Women with type 2 diabetes (T2D) show greater rates of mortality due to ischemic heart disease than men with T2D. We aimed to examine cardiovascular and autonomic function responses to isometric handgrip (IHG) exercise between men and women with T2D, before and after an exercise training program. Materials/Methods: Hemodynamic responses were measured in 22 men and women with T2D during and following a 3-min IHG test, and before and after 16 wks of aerobic exercise training. Results: Women had a smaller decrease in mean arterial pressure (MAP) and systolic blood pressure (BP) during recovery from IHG (ΔMAPREC) than men pre- and post-training (P < 0.05). Men showed a greater reduction in diastolic BP during recovery from IHG (P < 0.05), and exercise training improved this response in men but not in women (men, pre-training: - 13.9 ± 1.8, post-training: - 20.5 ± 5.3 mmHg vs. women, pre-training: - 10.7 ± 1.7, post-training: - 4.1 ± 4.9 mmHg; P < 0.05). Men had a greater reduction in sympathetic modulation of vasomotor tone (P < 0.05), as estimated by blood pressure variability, following IHG. This response was accentuated after training, while this training effect was not seen in women. Post-training ΔMAPREC was correlated with recovery of low frequency component of the BP spectrum (ΔLFSBPrec, r = 0.52, P < 0.05). Conclusions: Differences in BP recovery immediately following IHG may be attributed to gender differences in cardiovascular autonomic modulation. An improvement in these responses occurs following aerobic exercise training in obese men, but not in obese women with T2D which reflects a better adaptive autonomic response to exercise training.
AB - Objectives: Women with type 2 diabetes (T2D) show greater rates of mortality due to ischemic heart disease than men with T2D. We aimed to examine cardiovascular and autonomic function responses to isometric handgrip (IHG) exercise between men and women with T2D, before and after an exercise training program. Materials/Methods: Hemodynamic responses were measured in 22 men and women with T2D during and following a 3-min IHG test, and before and after 16 wks of aerobic exercise training. Results: Women had a smaller decrease in mean arterial pressure (MAP) and systolic blood pressure (BP) during recovery from IHG (ΔMAPREC) than men pre- and post-training (P < 0.05). Men showed a greater reduction in diastolic BP during recovery from IHG (P < 0.05), and exercise training improved this response in men but not in women (men, pre-training: - 13.9 ± 1.8, post-training: - 20.5 ± 5.3 mmHg vs. women, pre-training: - 10.7 ± 1.7, post-training: - 4.1 ± 4.9 mmHg; P < 0.05). Men had a greater reduction in sympathetic modulation of vasomotor tone (P < 0.05), as estimated by blood pressure variability, following IHG. This response was accentuated after training, while this training effect was not seen in women. Post-training ΔMAPREC was correlated with recovery of low frequency component of the BP spectrum (ΔLFSBPrec, r = 0.52, P < 0.05). Conclusions: Differences in BP recovery immediately following IHG may be attributed to gender differences in cardiovascular autonomic modulation. An improvement in these responses occurs following aerobic exercise training in obese men, but not in obese women with T2D which reflects a better adaptive autonomic response to exercise training.
KW - Blood pressure variability
KW - Exercise
KW - Mean arterial pressure
UR - http://www.scopus.com/inward/record.url?scp=84869505743&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2012.07.014
DO - 10.1016/j.metabol.2012.07.014
M3 - Article
C2 - 22902004
AN - SCOPUS:84869505743
SN - 0026-0495
VL - 61
SP - 1739
EP - 1746
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 12
ER -