Exercise training improves cardiovascular autonomic modulation in response to glucose ingestion in obese adults with and without type 2 diabetes mellitus

Styliani Goulopoulou, Tracy Baynard, Ruth M. Franklin, Bo Fernhall, Robert Carhart, Ruth Weinstock, Jill A. Kanaley

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25 Citations (Scopus)

Abstract

This study examined the effect of aerobic exercise training on vagal and sympathetic influences on the modulations of heart rate and systolic blood pressure in response to an oral glucose load in obese individuals with and without type 2 diabetes mellitus (T2D). Beat-to-beat arterial pressure and continuous electrocardiogram were measured after a 12-hour overnight fast and in response to glucose ingestion (75 g dextrose) in obese subjects with (T2D group, n = 23) and without (OB group, n = 36) T2D before and after 16 weeks of aerobic exercise training at moderate intensity. Autonomic modulation was assessed using spectral analysis of systolic blood pressure variability (BPV), heart rate variability (HRV), and analysis of baroreflex sensitivity (BRS). Glucose ingestion significantly increased low-frequency (LFSBP), low-frequency HRV (LFRRI), and the ratio of low- to high-frequency components of HRV (LFRRI/HFRRI), and decreased the high-frequency power (HFRRI) (P < .05). Exercise training increased LFRRI and LFRRI/HFRRI responses, and reduced HFRRI and LFSBP to glucose ingestion in both groups (P < .05), but increased fasted BRS in the OB group only (P < .05); glucose intake had no effect on BRS (P > .05). In conclusion, a 16-week exercise training program improved cardiac autonomic modulation in response to an oral glucose load in obese adults, independently of diabetes status, and in the absence of remarkable changes in body weight, body composition, fitness level, and glycemic control.

Original languageEnglish
Pages (from-to)901-910
Number of pages10
JournalMetabolism: Clinical and Experimental
Volume59
Issue number6
DOIs
StatePublished - 1 Jun 2010

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Type 2 Diabetes Mellitus
Eating
Exercise
Glucose
Heart Rate
Blood Pressure
Body Weight Changes
Baroreflex
Status Epilepticus
Body Composition
Arterial Pressure
Electrocardiography
Education

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Goulopoulou, Styliani ; Baynard, Tracy ; Franklin, Ruth M. ; Fernhall, Bo ; Carhart, Robert ; Weinstock, Ruth ; Kanaley, Jill A. / Exercise training improves cardiovascular autonomic modulation in response to glucose ingestion in obese adults with and without type 2 diabetes mellitus. In: Metabolism: Clinical and Experimental. 2010 ; Vol. 59, No. 6. pp. 901-910.
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Exercise training improves cardiovascular autonomic modulation in response to glucose ingestion in obese adults with and without type 2 diabetes mellitus. / Goulopoulou, Styliani; Baynard, Tracy; Franklin, Ruth M.; Fernhall, Bo; Carhart, Robert; Weinstock, Ruth; Kanaley, Jill A.

In: Metabolism: Clinical and Experimental, Vol. 59, No. 6, 01.06.2010, p. 901-910.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Exercise training improves cardiovascular autonomic modulation in response to glucose ingestion in obese adults with and without type 2 diabetes mellitus

AU - Goulopoulou, Styliani

AU - Baynard, Tracy

AU - Franklin, Ruth M.

AU - Fernhall, Bo

AU - Carhart, Robert

AU - Weinstock, Ruth

AU - Kanaley, Jill A.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - This study examined the effect of aerobic exercise training on vagal and sympathetic influences on the modulations of heart rate and systolic blood pressure in response to an oral glucose load in obese individuals with and without type 2 diabetes mellitus (T2D). Beat-to-beat arterial pressure and continuous electrocardiogram were measured after a 12-hour overnight fast and in response to glucose ingestion (75 g dextrose) in obese subjects with (T2D group, n = 23) and without (OB group, n = 36) T2D before and after 16 weeks of aerobic exercise training at moderate intensity. Autonomic modulation was assessed using spectral analysis of systolic blood pressure variability (BPV), heart rate variability (HRV), and analysis of baroreflex sensitivity (BRS). Glucose ingestion significantly increased low-frequency (LFSBP), low-frequency HRV (LFRRI), and the ratio of low- to high-frequency components of HRV (LFRRI/HFRRI), and decreased the high-frequency power (HFRRI) (P < .05). Exercise training increased LFRRI and LFRRI/HFRRI responses, and reduced HFRRI and LFSBP to glucose ingestion in both groups (P < .05), but increased fasted BRS in the OB group only (P < .05); glucose intake had no effect on BRS (P > .05). In conclusion, a 16-week exercise training program improved cardiac autonomic modulation in response to an oral glucose load in obese adults, independently of diabetes status, and in the absence of remarkable changes in body weight, body composition, fitness level, and glycemic control.

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JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

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