Evidence for stroke-induced neurogenesis in the human brain

Kunlin Jin; Xiaomei Wang; Lin Xie; Xiao Ou Mao; Wei Zhu; Yin Wang; Jianfeng Shen; Ying Mao; Surita Banwait; David A. Greenberg

doi:10.1073/pnas.0603512103

Evidence for stroke-induced neurogenesis in the human brain

Kunlin Jin, Xiaomei Wang, Lin Xie, Xiao Ou Mao, Wei Zhu, Yin Wang, Jianfeng Shen, Ying Mao, Surita Banwait, David A. Greenberg

Research output: Contribution to journal › Article › peer-review

518 Scopus citations

Abstract

Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.

Original language	English
Pages (from-to)	13198-13202
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	103
Issue number	35
DOIs	https://doi.org/10.1073/pnas.0603512103
State	Published - 29 Aug 2006

Keywords

Infarct
Ischemia
Penumbra
Stem cells
Vascular niche

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title = "Evidence for stroke-induced neurogenesis in the human brain",

abstract = "Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.",

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T1 - Evidence for stroke-induced neurogenesis in the human brain

AU - Jin, Kunlin

AU - Wang, Xiaomei

AU - Xie, Lin

AU - Mao, Xiao Ou

AU - Zhu, Wei

AU - Wang, Yin

AU - Shen, Jianfeng

AU - Mao, Ying

AU - Banwait, Surita

AU - Greenberg, David A.

PY - 2006/8/29

Y1 - 2006/8/29

N2 - Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.

AB - Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.

KW - Infarct

KW - Ischemia

KW - Penumbra

KW - Stem cells

KW - Vascular niche

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 35

ER -

Evidence for stroke-induced neurogenesis in the human brain

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Keywords

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