Evidence for stroke-induced neurogenesis in the human brain

Kunlin Jin, Xiaomei Wang, Lin Xie, Xiao Ou Mao, Wei Zhu, Yin Wang, Jianfeng Shen, Ying Mao, Surita Banwait, David A. Greenberg

Research output: Contribution to journalArticle

441 Scopus citations

Abstract

Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.

Original languageEnglish
Pages (from-to)13198-13202
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number35
DOIs
StatePublished - 29 Aug 2006

Keywords

  • Infarct
  • Ischemia
  • Penumbra
  • Stem cells
  • Vascular niche

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  • Cite this

    Jin, K., Wang, X., Xie, L., Mao, X. O., Zhu, W., Wang, Y., Shen, J., Mao, Y., Banwait, S., & Greenberg, D. A. (2006). Evidence for stroke-induced neurogenesis in the human brain. Proceedings of the National Academy of Sciences of the United States of America, 103(35), 13198-13202. https://doi.org/10.1073/pnas.0603512103