Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: An in vivo microdialysis study

Vien Nguyen, Alevtina D. Zharikova, Laszlo Prokai

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Abstract

Local perfusion of pGlu-Glu-Pro-NH2, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat hippocampus did not change the basal level of extracellular acetylcholine. However, co-perfusion of pGlu-Glu-Pro-NH2 with TRH in equimolar concentrations yielded a significant attenuation of TRH-induced acetylcholine release. The results have supported the study's hypothesis that pGlu-Glu-Pro-NH2 opposes the cholinergic effect of TRH in the mammalian central nervous system. The enantiomer pGlu-d-Glu-Pro-NH2 affected neither basal extracellular nor TRH-induced increase of acetylcholine levels.

Original languageEnglish
Pages (from-to)64-67
Number of pages4
JournalNeuroscience letters
Volume415
Issue number1
DOIs
StatePublished - 19 Mar 2007

Keywords

  • Acetylcholine release
  • Neuromodulator
  • TRH
  • TRH analogue

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