Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: An in vivo microdialysis study

Vien Nguyen; Alevtina D. Zharikova; Laszlo Prokai

doi:10.1016/j.neulet.2006.12.039

Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH₂ ([Glu²]TRH) in the brain: An in vivo microdialysis study

Vien Nguyen, Alevtina D. Zharikova, Laszlo Prokai

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Local perfusion of pGlu-Glu-Pro-NH₂, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat hippocampus did not change the basal level of extracellular acetylcholine. However, co-perfusion of pGlu-Glu-Pro-NH₂ with TRH in equimolar concentrations yielded a significant attenuation of TRH-induced acetylcholine release. The results have supported the study's hypothesis that pGlu-Glu-Pro-NH₂ opposes the cholinergic effect of TRH in the mammalian central nervous system. The enantiomer pGlu-d-Glu-Pro-NH₂ affected neither basal extracellular nor TRH-induced increase of acetylcholine levels.

Original language	English
Pages (from-to)	64-67
Number of pages	4
Journal	Neuroscience letters
Volume	415
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2006.12.039
State	Published - 19 Mar 2007

Keywords

Acetylcholine release
Neuromodulator
TRH
TRH analogue

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title = "Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: An in vivo microdialysis study",

abstract = "Local perfusion of pGlu-Glu-Pro-NH2, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat hippocampus did not change the basal level of extracellular acetylcholine. However, co-perfusion of pGlu-Glu-Pro-NH2 with TRH in equimolar concentrations yielded a significant attenuation of TRH-induced acetylcholine release. The results have supported the study's hypothesis that pGlu-Glu-Pro-NH2 opposes the cholinergic effect of TRH in the mammalian central nervous system. The enantiomer pGlu-d-Glu-Pro-NH2 affected neither basal extracellular nor TRH-induced increase of acetylcholine levels.",

keywords = "Acetylcholine release, Neuromodulator, TRH, TRH analogue",

author = "Vien Nguyen and Zharikova, {Alevtina D.} and Laszlo Prokai",

note = "Funding Information: This study was supported by the National Institutes of Health (Bethesda, MD, USA) grant MH59360. Laszlo Prokai is the Robert A. Welch Professor at the University of North Texas Health Science Center.",

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T2 - An in vivo microdialysis study

AU - Nguyen, Vien

AU - Zharikova, Alevtina D.

AU - Prokai, Laszlo

N1 - Funding Information: This study was supported by the National Institutes of Health (Bethesda, MD, USA) grant MH59360. Laszlo Prokai is the Robert A. Welch Professor at the University of North Texas Health Science Center.

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N2 - Local perfusion of pGlu-Glu-Pro-NH2, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat hippocampus did not change the basal level of extracellular acetylcholine. However, co-perfusion of pGlu-Glu-Pro-NH2 with TRH in equimolar concentrations yielded a significant attenuation of TRH-induced acetylcholine release. The results have supported the study's hypothesis that pGlu-Glu-Pro-NH2 opposes the cholinergic effect of TRH in the mammalian central nervous system. The enantiomer pGlu-d-Glu-Pro-NH2 affected neither basal extracellular nor TRH-induced increase of acetylcholine levels.

AB - Local perfusion of pGlu-Glu-Pro-NH2, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat hippocampus did not change the basal level of extracellular acetylcholine. However, co-perfusion of pGlu-Glu-Pro-NH2 with TRH in equimolar concentrations yielded a significant attenuation of TRH-induced acetylcholine release. The results have supported the study's hypothesis that pGlu-Glu-Pro-NH2 opposes the cholinergic effect of TRH in the mammalian central nervous system. The enantiomer pGlu-d-Glu-Pro-NH2 affected neither basal extracellular nor TRH-induced increase of acetylcholine levels.

KW - Acetylcholine release

KW - Neuromodulator

KW - TRH

KW - TRH analogue

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JO - Neuroscience Letters

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ER -

Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH₂ ([Glu²]TRH) in the brain: An in vivo microdialysis study

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Keywords

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