Abstract
Local perfusion of pGlu-Glu-Pro-NH2, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat hippocampus did not change the basal level of extracellular acetylcholine. However, co-perfusion of pGlu-Glu-Pro-NH2 with TRH in equimolar concentrations yielded a significant attenuation of TRH-induced acetylcholine release. The results have supported the study's hypothesis that pGlu-Glu-Pro-NH2 opposes the cholinergic effect of TRH in the mammalian central nervous system. The enantiomer pGlu-d-Glu-Pro-NH2 affected neither basal extracellular nor TRH-induced increase of acetylcholine levels.
Original language | English |
---|---|
Pages (from-to) | 64-67 |
Number of pages | 4 |
Journal | Neuroscience letters |
Volume | 415 |
Issue number | 1 |
DOIs | |
State | Published - 19 Mar 2007 |
Keywords
- Acetylcholine release
- Neuromodulator
- TRH
- TRH analogue