Evidence for dopaminergic involvement in tolerance to the discriminative stimulus properties of cocaine

Douglas M. Wood, Michael W. Emmett-Oglesby

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Rats were trained to discriminate cocaine, 10.0 mg/kg, in a two-lever operant procedure. Dose-effect data for generalization to cocaine and substitution of apomorphine for the cocaine stimulus were determined. Subsequently, training was halted and either apomorphine, 2.5 mg/kg per 8 h, or cocaine, 20 mg/kg per 8 h, was administered for 7-9 days. During chronic administration, the efficacy of cocaine and apomorphine as discriminative stimuli was decreased. These data suggest that dopaminergic mechanisms may mediate tolerance to the discriminative stimulus properties of cocaine.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalEuropean Journal of Pharmacology
Volume138
Issue number1
DOIs
StatePublished - 12 Jun 1987

Keywords

  • (Rat)
  • Apomorphine
  • Cocaine
  • Drug discrimination
  • Tolerance

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