TY - JOUR
T1 - Evidence for dopaminergic involvement in tolerance to the discriminative stimulus properties of cocaine
AU - Wood, Douglas M.
AU - Emmett-Oglesby, Michael W.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1987/6/12
Y1 - 1987/6/12
N2 - Rats were trained to discriminate cocaine, 10.0 mg/kg, in a two-lever operant procedure. Dose-effect data for generalization to cocaine and substitution of apomorphine for the cocaine stimulus were determined. Subsequently, training was halted and either apomorphine, 2.5 mg/kg per 8 h, or cocaine, 20 mg/kg per 8 h, was administered for 7-9 days. During chronic administration, the efficacy of cocaine and apomorphine as discriminative stimuli was decreased. These data suggest that dopaminergic mechanisms may mediate tolerance to the discriminative stimulus properties of cocaine.
AB - Rats were trained to discriminate cocaine, 10.0 mg/kg, in a two-lever operant procedure. Dose-effect data for generalization to cocaine and substitution of apomorphine for the cocaine stimulus were determined. Subsequently, training was halted and either apomorphine, 2.5 mg/kg per 8 h, or cocaine, 20 mg/kg per 8 h, was administered for 7-9 days. During chronic administration, the efficacy of cocaine and apomorphine as discriminative stimuli was decreased. These data suggest that dopaminergic mechanisms may mediate tolerance to the discriminative stimulus properties of cocaine.
KW - (Rat)
KW - Apomorphine
KW - Cocaine
KW - Drug discrimination
KW - Tolerance
UR - http://www.scopus.com/inward/record.url?scp=0023178444&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(87)90354-2
DO - 10.1016/0014-2999(87)90354-2
M3 - Article
C2 - 3622606
AN - SCOPUS:0023178444
SN - 0014-2999
VL - 138
SP - 155
EP - 157
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -