@article{7116fbd7497746fcabee5a5fa231bc73,
title = "Evaluation of the National Task Group-Early Detection Screen for Dementia: Sensitivity to {\textquoteleft}mild cognitive impairment{\textquoteright} in adults with Down syndrome",
abstract = "Background: The accuracy of the National Task Group-Early Detection Screen for Dementia (NTG-EDSD) was evaluated in a sample of 185 adults with Down syndrome (DS), emphasizing {\textquoteleft}mild cognitive impairment (MCI-DS){\textquoteright}. Method: Knowledgeable informants were interviewed with the NTG-EDSD, and findings were compared to an independent dementia status rating based on consensus review of detailed assessments of cognition, functional abilities and health status (including physician examination). Results: Results indicated that sections of the NTG-EDSD were sensitive to MCI-DS, with one or more concerns within the {\textquoteleft}Memory{\textquoteright} or {\textquoteleft}Language and Communication{\textquoteright} domains being most informative. Conclusions: The NTG-EDSD is a useful tool for evaluating dementia status, including MCI-DS. However, estimates of sensitivity and specificity, even for detecting frank dementia, indicated that NTG-EDSD findings need to be supplemented by additional sources of relevant information to achieve an acceptable level of diagnostic/screening accuracy.",
keywords = "Alzheimer's disease, NTG-EDSD, dementia, down syndrome, mild cognitive impairment",
author = "{The Alzheimer{\textquoteright}s Disease in Down Syndrome (ADDS) Consortium} and Wayne Silverman and Krinsky-McHale, {Sharon J.} and Florence Lai and {Diana Rosas}, H. and Christy Hom and Eric Doran and Margaret Pulsifer and Ira Lott and Nicole Schupf and Howard Andrews and Karen Bell and Adam Brickman and Patrick Lao and Kreisl, {William Charles} and Lawrence Honig and Lorraine Clark and David Keator and Elizabeth Head and Mark Mapstone and Sid O{\textquoteright}Bryant and Melissa Petersen and Qolamreza Rezlighi and Benjamin Tycko and Badri Varadarajan and Wang, {Mei Cheng} and Michael Yassa",
note = "Funding Information: Additional members of the ADDS consortium: Drs. Howard Andrews, Karen Bell, Adam Brickman, Patrick Lao, William Charles Kreisl, Lawrence Honig, Lorraine Clark, David Keator, Elizabeth Head, Mark Mapstone, Sid, O{\textquoteright}Bryant, Melissa Petersen, Qolamreza Rezlighi, Benjamin Tycko, Badri Varadarajan, Mei‐Cheng Wang and Michael Yassa. The ADDS programme, a component of the Alzheimer{\textquoteright}s Biomarkers Consortium—Down Syndrome (ABC‐DS), is supported by a grant from the National Institute on Aging and the National Institute for Child Health and Human Development (U01 AG051412). The work contained in this publication also received support from the following National Institutes of Health Research Centers (P50 AG008702, P30 AG062421, P50 AG16537, U54 HD079123, UL1TR001873, UL1 TR001414) as well as DS‐Connect{\textregistered} (The Down Syndrome Registry) supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. This work was also supported by the New York State Office for People with Developmental Disabilities. The authors thank the adults with Down syndrome volunteering as participants in this study for their invaluable contributions to this work, as well as their families and care providers, for their generous support. Drs. Silverman, Krinsky‐McHale, Schupf and Lee would also like to thank Deborah Pang, Tracy Listwan, Cynthia Kovacs and Lisa Kullman for their invaluable contributions to our programme. The content of this paper is the sole responsibility of the authors and does not necessarily represent the official views of the NIH. Eunice Kennedy Shriver Funding Information: Drs. Silverman and Krinsky-McHale contributed equally to this paper. Additional members of the ADDS consortium: Drs. Howard Andrews, Karen Bell, Adam Brickman, Patrick Lao, William Charles Kreisl, Lawrence Honig, Lorraine Clark, David Keator, Elizabeth Head, Mark Mapstone, Sid, O{\textquoteright}Bryant, Melissa Petersen, Qolamreza Rezlighi, Benjamin Tycko, Badri Varadarajan, Mei-Cheng Wang and Michael Yassa. The ADDS programme, a component of the Alzheimer{\textquoteright}s Biomarkers Consortium—Down Syndrome (ABC-DS), is supported by a grant from the National Institute on Aging and the Eunice Kennedy Shriver National Institute for Child Health and Human Development (U01 AG051412). The work contained in this publication also received support from the following National Institutes of Health Research Centers (P50 AG008702, P30 AG062421, P50 AG16537, U54 HD079123, UL1TR001873, UL1 TR001414) as well as DS-Connect{\textregistered} (The Down Syndrome Registry) supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. This work was also supported by the New York State Office for People with Developmental Disabilities. The authors thank the adults with Down syndrome volunteering as participants in this study for their invaluable contributions to this work, as well as their families and care providers, for their generous support. Drs. Silverman, Krinsky-McHale, Schupf and Lee would also like to thank Deborah Pang, Tracy Listwan, Cynthia Kovacs and Lisa Kullman for their invaluable contributions to our programme. The content of this paper is the sole responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons Ltd",
year = "2021",
month = may,
doi = "10.1111/jar.12849",
language = "English",
volume = "34",
pages = "905--915",
journal = "Journal of Applied Research in Intellectual Disabilities",
issn = "1360-2322",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",
}