TY - JOUR
T1 - Evaluation of the in-vitro antibacterial activity of Sch 34343
AU - Adam, C.
AU - Naples, L.
AU - Weiss, W.
AU - Sabatelli, F.
AU - Hare, R.
AU - Loebenberg, D.
AU - Miller, G. H.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - The in-vitro activity (as measured by geometric mean MICs, mg/l) of Sch 34343 against aerobic and anaerobic bacteria was compared with that of 14 other selected β-lactam antibiotics including aztreonam, latamoxef (moxalactam), ceftazidime and imipenem. Sch 34343 had good activity (< 2 mg/l) against most Gram-negative aerobic bacteria whether or not they contained high levels of plasmid-mediated or chromosomally-mediated β-lactamases. It was slightly less potent against strains of Morganella and Serratia (< 4 mg/l) and inactive against Pseudomonas (> 64 mg/l). A very small inoculum effect was observed against strains containing β-lactamases indicating stability. Unlike the third-generation cephalosporins, Sch 34343 had excellent activity (≤ 0.18 mg/l) against staphylococci, comparable to that of imipenem and ampicillin. While Sch 34343 had equally good potency (0.17 mg/l) against penicillinase-positive staphylococci, it was inactive against methicillin-resistant staphylococci (≥ 35 mg/l). Sch 34343 also had good activity against streptococci. The most unusual aspect of the in-vitro activity was its activity against Bacteroides (including Bact. fragilis) and other anaerobes. Sch 34343 had mean MICs ≤ 0.1 mg/l for all Bacteroides and Clostridium spp. tested except Cl. difficile (3.4 mg/l).
AB - The in-vitro activity (as measured by geometric mean MICs, mg/l) of Sch 34343 against aerobic and anaerobic bacteria was compared with that of 14 other selected β-lactam antibiotics including aztreonam, latamoxef (moxalactam), ceftazidime and imipenem. Sch 34343 had good activity (< 2 mg/l) against most Gram-negative aerobic bacteria whether or not they contained high levels of plasmid-mediated or chromosomally-mediated β-lactamases. It was slightly less potent against strains of Morganella and Serratia (< 4 mg/l) and inactive against Pseudomonas (> 64 mg/l). A very small inoculum effect was observed against strains containing β-lactamases indicating stability. Unlike the third-generation cephalosporins, Sch 34343 had excellent activity (≤ 0.18 mg/l) against staphylococci, comparable to that of imipenem and ampicillin. While Sch 34343 had equally good potency (0.17 mg/l) against penicillinase-positive staphylococci, it was inactive against methicillin-resistant staphylococci (≥ 35 mg/l). Sch 34343 also had good activity against streptococci. The most unusual aspect of the in-vitro activity was its activity against Bacteroides (including Bact. fragilis) and other anaerobes. Sch 34343 had mean MICs ≤ 0.1 mg/l for all Bacteroides and Clostridium spp. tested except Cl. difficile (3.4 mg/l).
UR - http://www.scopus.com/inward/record.url?scp=0021875955&partnerID=8YFLogxK
U2 - 10.1093/jac/15.suppl_c.39
DO - 10.1093/jac/15.suppl_c.39
M3 - Article
C2 - 3875604
AN - SCOPUS:0021875955
SN - 0305-7453
VL - 15
SP - 39
EP - 56
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - SUPPL. C
ER -