Evaluation of the in-vitro antibacterial activity of Sch 34343

C. Adam, L. Naples, W. Weiss, F. Sabatelli, R. Hare, D. Loebenberg, G. H. Miller

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Abstract

The in-vitro activity (as measured by geometric mean MICs, mg/l) of Sch 34343 against aerobic and anaerobic bacteria was compared with that of 14 other selected β-lactam antibiotics including aztreonam, latamoxef (moxalactam), ceftazidime and imipenem. Sch 34343 had good activity (< 2 mg/l) against most Gram-negative aerobic bacteria whether or not they contained high levels of plasmid-mediated or chromosomally-mediated β-lactamases. It was slightly less potent against strains of Morganella and Serratia (< 4 mg/l) and inactive against Pseudomonas (> 64 mg/l). A very small inoculum effect was observed against strains containing β-lactamases indicating stability. Unlike the third-generation cephalosporins, Sch 34343 had excellent activity (≤ 0.18 mg/l) against staphylococci, comparable to that of imipenem and ampicillin. While Sch 34343 had equally good potency (0.17 mg/l) against penicillinase-positive staphylococci, it was inactive against methicillin-resistant staphylococci (≥ 35 mg/l). Sch 34343 also had good activity against streptococci. The most unusual aspect of the in-vitro activity was its activity against Bacteroides (including Bact. fragilis) and other anaerobes. Sch 34343 had mean MICs ≤ 0.1 mg/l for all Bacteroides and Clostridium spp. tested except Cl. difficile (3.4 mg/l).

Original languageEnglish
Pages (from-to)39-56
Number of pages18
JournalJournal of Antimicrobial Chemotherapy
Volume15
Issue numberSUPPL. C
DOIs
StatePublished - 1 Jan 1985

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    Adam, C., Naples, L., Weiss, W., Sabatelli, F., Hare, R., Loebenberg, D., & Miller, G. H. (1985). Evaluation of the in-vitro antibacterial activity of Sch 34343. Journal of Antimicrobial Chemotherapy, 15(SUPPL. C), 39-56. https://doi.org/10.1093/jac/15.suppl_c.39