Abstract
Reconstituted (synthetic) high-density lipoprotein particles carrying paclitaxel (rHDL/PTX) were prepared with substantially higher PTX content than reported earlier. The rHDL/PTX complexes seemed to be primarily spherical nanoparticles when examined via electron microscopy, with a constant composition, molecular weight and exceptional stability even after ultracentrifugation and storage for up to 6 months. The rHDL/PTX nanoparticles had superior cytotoxicity against several cancer cell lines (MCF7, DU145, OV1063 and OVCAR-3), the half maximal inhibitory concentration (IC50) having been found to be 5-20 times lower than that of the free drug. Studies with mice showed that the rHDL/PTX nanoparticles were substantially better tolerated than the corresponding dosages of either Taxol or Abraxane.
Original language | English |
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Pages (from-to) | 183-188 |
Number of pages | 6 |
Journal | Anti-Cancer Drugs |
Volume | 19 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2008 |
Keywords
- Chemotherapy
- Drug delivery
- Nanoparticles
- Reconstituted (synthetic) high-density lipoprotein