Evaluation of synthetic/reconstituted high-density lipoproteins as delivery vehicles for paclitaxel

Walter J. McConathy; Maya P. Nair; Sulabha Paranjape; Linda Mooberry; Andras G. Lacko

doi:10.1097/CAD.0b013e3282f1da86

Evaluation of synthetic/reconstituted high-density lipoproteins as delivery vehicles for paclitaxel

Walter J. McConathy, Maya P. Nair, Sulabha Paranjape, Linda Mooberry, Andras G. Lacko

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Reconstituted (synthetic) high-density lipoprotein particles carrying paclitaxel (rHDL/PTX) were prepared with substantially higher PTX content than reported earlier. The rHDL/PTX complexes seemed to be primarily spherical nanoparticles when examined via electron microscopy, with a constant composition, molecular weight and exceptional stability even after ultracentrifugation and storage for up to 6 months. The rHDL/PTX nanoparticles had superior cytotoxicity against several cancer cell lines (MCF7, DU145, OV1063 and OVCAR-3), the half maximal inhibitory concentration (IC50) having been found to be 5-20 times lower than that of the free drug. Studies with mice showed that the rHDL/PTX nanoparticles were substantially better tolerated than the corresponding dosages of either Taxol or Abraxane.

Original language	English
Pages (from-to)	183-188
Number of pages	6
Journal	Anti-Cancer Drugs
Volume	19
Issue number	2
DOIs	https://doi.org/10.1097/CAD.0b013e3282f1da86
State	Published - Feb 2008

Keywords

Chemotherapy
Drug delivery
Nanoparticles
Reconstituted (synthetic) high-density lipoprotein

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10.1097/CAD.0b013e3282f1da86

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abstract = "Reconstituted (synthetic) high-density lipoprotein particles carrying paclitaxel (rHDL/PTX) were prepared with substantially higher PTX content than reported earlier. The rHDL/PTX complexes seemed to be primarily spherical nanoparticles when examined via electron microscopy, with a constant composition, molecular weight and exceptional stability even after ultracentrifugation and storage for up to 6 months. The rHDL/PTX nanoparticles had superior cytotoxicity against several cancer cell lines (MCF7, DU145, OV1063 and OVCAR-3), the half maximal inhibitory concentration (IC50) having been found to be 5-20 times lower than that of the free drug. Studies with mice showed that the rHDL/PTX nanoparticles were substantially better tolerated than the corresponding dosages of either Taxol or Abraxane.",

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Evaluation of synthetic/reconstituted high-density lipoproteins as delivery vehicles for paclitaxel

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Keywords

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