Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea

Tarcisius Uluk; Waridibo E. Allison; John Vince; Handan Wand; Nakapi Tefuarani; Louise M. Causer; Paulus Ripa; Maylene Kariko; Oscillah Kaminiel; Philip Cunningham; Steve M. Graham; John M. Kaldor

doi:10.1097/INF.0b013e31827412fc

Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea

Tarcisius Uluk, Waridibo E. Allison, John Vince, Handan Wand, Nakapi Tefuarani, Louise M. Causer, Paulus Ripa, Maylene Kariko, Oscillah Kaminiel, Philip Cunningham, Steve M. Graham, John M. Kaldor

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3 Scopus citations

Abstract

There are few data from tuberculosis (TB) endemic settings of the performance and outcome predictors of the QuantiFERON-TB Gold in Tube assay (QFT) in children with suspected TB. A prospective cross-sectional study was conducted in Papua New Guinea children with suspected TB evaluated at Port Moresby General Hospital (Port Moresby, Papua New Guinea). Two hundred sixteen children were enrolled including 106 probable TB, 87 possible TB and 23 without TB. Concordance between QFT and tuberculin skin test results was 86% (P < 0.001, κ = 0.70). QFT was significantly more likely to be positive than tuberculin skin test, overall and within the probable or possible TB categories, with no difference in prevalence of positivity between these 2 categories. The role of QFT in supporting the clinical diagnosis of TB in endemic settings, where resources are limited, remains uncertain especially as cost and technical requirements remain considerable.

Original language	English
Pages (from-to)	187-189
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	32
Issue number	2
DOIs	https://doi.org/10.1097/INF.0b013e31827412fc
State	Published - Feb 2013

Keywords

children
HIV
interferon gamma release assay
Papua New Guinea
tuberculin skin test
tuberculosis

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10.1097/INF.0b013e31827412fc

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Uluk, T., Allison, W. E., Vince, J., Wand, H., Tefuarani, N., Causer, L. M., Ripa, P., Kariko, M., Kaminiel, O., Cunningham, P., Graham, S. M., & Kaldor, J. M. (2013). Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea. Pediatric Infectious Disease Journal, 32(2), 187-189. https://doi.org/10.1097/INF.0b013e31827412fc

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title = "Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea",

abstract = "There are few data from tuberculosis (TB) endemic settings of the performance and outcome predictors of the QuantiFERON-TB Gold in Tube assay (QFT) in children with suspected TB. A prospective cross-sectional study was conducted in Papua New Guinea children with suspected TB evaluated at Port Moresby General Hospital (Port Moresby, Papua New Guinea). Two hundred sixteen children were enrolled including 106 probable TB, 87 possible TB and 23 without TB. Concordance between QFT and tuberculin skin test results was 86% (P < 0.001, κ = 0.70). QFT was significantly more likely to be positive than tuberculin skin test, overall and within the probable or possible TB categories, with no difference in prevalence of positivity between these 2 categories. The role of QFT in supporting the clinical diagnosis of TB in endemic settings, where resources are limited, remains uncertain especially as cost and technical requirements remain considerable.",

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AU - Causer, Louise M.

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AB - There are few data from tuberculosis (TB) endemic settings of the performance and outcome predictors of the QuantiFERON-TB Gold in Tube assay (QFT) in children with suspected TB. A prospective cross-sectional study was conducted in Papua New Guinea children with suspected TB evaluated at Port Moresby General Hospital (Port Moresby, Papua New Guinea). Two hundred sixteen children were enrolled including 106 probable TB, 87 possible TB and 23 without TB. Concordance between QFT and tuberculin skin test results was 86% (P < 0.001, κ = 0.70). QFT was significantly more likely to be positive than tuberculin skin test, overall and within the probable or possible TB categories, with no difference in prevalence of positivity between these 2 categories. The role of QFT in supporting the clinical diagnosis of TB in endemic settings, where resources are limited, remains uncertain especially as cost and technical requirements remain considerable.

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Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea

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