Evaluation of a twice-a-week application of 1% niclosamide lotion in preventing Schistosoma haematobium reinfection

J. K. Podgore, R. R. Abu-Elyazeed, N. S. Mansour, F. G. Youssef, R. G. Hibbs, J. A. Gere

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A randomized double-blind trial was conducted to assess the efficacy of a twice-a-week application of 1% niclosamide lotion for prevention of Schistosoma haematobium reinfection. Six hundred farmers in Fayoum, Egypt, 18-40 years of age, were treated to cure their S. haematobium infection, then randomly assigned to self-apply niclosamide or placebo lotion to their limbs, neck, and torso. Subjects were exposed to schistosomal-infested water during routine irrigation activities from April to October 1992. Three hundred fifty subjects met the inclusion criteria and completed the trial, 169 (48.3%) in the niclosamide group and 181 (51.7%) in the placebo group. The subjects assigned to the niclosamide-treated group were comparable with those in the placebo group in age (27.2 versus 27.8 years), total water contact (101.9 versus 109.0 hr), lotion application compliance (93.5% versus 90.6%), and avoidance of whole body water contact (94.7% versus 96.7%). The reinfection rate with S. haematobium was 30.8% in the niclosamide-treated group and 28.2% in the placebo group. Niclosamide lotion applied to the limbs and trunk twice a week failed to prevent S. haematobium reinfection.

Original languageEnglish
Pages (from-to)875-879
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume51
Issue number6
DOIs
StatePublished - 1 Jan 1994

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