TY - JOUR
T1 - Evaluation of 13 short tandem repeat loci for use in personal identification applications
AU - Hammond, Holly A.
AU - Jin, Li
AU - Zhong, Y.
AU - Thomas Caskey, C.
AU - Chakraborty, Ranajit
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1994
Y1 - 1994
N2 - Personal identification by using DNA typing methodologies has been an issue in the popular and scientific press for several years. We present a PCR-based DNA-typing method using 13 unlinked short tandem repeat (STR) loci. Validation of the loci and methodology has been performed to meet standards set by the forensic community and the accrediting organization for parentage testing. Extensive statistical analysis has addressed the issues surrounding the presentation of 'match' statistics. We have found STR loci to provide a rapid, sensitive, and reliable method of DNA typing for parentage testing, forensic identification, and medical diagnostics. Valid statistical analysis is generally simpler than similar analysis of RFLP-VNTR results and provides powerful statistical evidence of the low frequency of random multilocus genotype matching.
AB - Personal identification by using DNA typing methodologies has been an issue in the popular and scientific press for several years. We present a PCR-based DNA-typing method using 13 unlinked short tandem repeat (STR) loci. Validation of the loci and methodology has been performed to meet standards set by the forensic community and the accrediting organization for parentage testing. Extensive statistical analysis has addressed the issues surrounding the presentation of 'match' statistics. We have found STR loci to provide a rapid, sensitive, and reliable method of DNA typing for parentage testing, forensic identification, and medical diagnostics. Valid statistical analysis is generally simpler than similar analysis of RFLP-VNTR results and provides powerful statistical evidence of the low frequency of random multilocus genotype matching.
UR - http://www.scopus.com/inward/record.url?scp=0028085643&partnerID=8YFLogxK
M3 - Article
C2 - 7912887
AN - SCOPUS:0028085643
SN - 0002-9297
VL - 55
SP - 175
EP - 189
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 1
ER -