Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondria

Talisa K. Silzer, Nicole Ruth Phillips

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Type 2 diabetes is a significant risk factor for developing Alzheimer's disease later in life, and particular populations have a disproportionate risk because of the high prevalence of type 2 diabetes. There are many overlapping pathologies, and teasing out the primary root cause, if one indeed exists, is very difficult. Here, we review (1) the key facets of mitochondrial biology that are relevant to the two conditions, and (2) the role that mitochondrial dysfunction plays in the shared pathophysiology. We posit that mitochondrial dysfunction lies at the root of the affected processes rather than alongside them as a co-pathology.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalMitochondrion
Volume43
DOIs
StatePublished - 1 Nov 2018

Fingerprint

Type 2 Diabetes Mellitus
Alzheimer Disease
Mitochondria
Pathology
Population

Keywords

  • Aging
  • Alzheimer's disease
  • Comorbidity
  • Mitochondria
  • Mitochondrial DNA
  • Type 2 diabetes

Cite this

@article{75bed950c77f4398859d7cb7a5362ee1,
title = "Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondria",
abstract = "Type 2 diabetes is a significant risk factor for developing Alzheimer's disease later in life, and particular populations have a disproportionate risk because of the high prevalence of type 2 diabetes. There are many overlapping pathologies, and teasing out the primary root cause, if one indeed exists, is very difficult. Here, we review (1) the key facets of mitochondrial biology that are relevant to the two conditions, and (2) the role that mitochondrial dysfunction plays in the shared pathophysiology. We posit that mitochondrial dysfunction lies at the root of the affected processes rather than alongside them as a co-pathology.",
keywords = "Aging, Alzheimer's disease, Comorbidity, Mitochondria, Mitochondrial DNA, Type 2 diabetes",
author = "Silzer, {Talisa K.} and Phillips, {Nicole Ruth}",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.mito.2018.04.004",
language = "English",
volume = "43",
pages = "16--24",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier",

}

Etiology of type 2 diabetes and Alzheimer's disease : Exploring the mitochondria. / Silzer, Talisa K.; Phillips, Nicole Ruth.

In: Mitochondrion, Vol. 43, 01.11.2018, p. 16-24.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Etiology of type 2 diabetes and Alzheimer's disease

T2 - Exploring the mitochondria

AU - Silzer, Talisa K.

AU - Phillips, Nicole Ruth

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Type 2 diabetes is a significant risk factor for developing Alzheimer's disease later in life, and particular populations have a disproportionate risk because of the high prevalence of type 2 diabetes. There are many overlapping pathologies, and teasing out the primary root cause, if one indeed exists, is very difficult. Here, we review (1) the key facets of mitochondrial biology that are relevant to the two conditions, and (2) the role that mitochondrial dysfunction plays in the shared pathophysiology. We posit that mitochondrial dysfunction lies at the root of the affected processes rather than alongside them as a co-pathology.

AB - Type 2 diabetes is a significant risk factor for developing Alzheimer's disease later in life, and particular populations have a disproportionate risk because of the high prevalence of type 2 diabetes. There are many overlapping pathologies, and teasing out the primary root cause, if one indeed exists, is very difficult. Here, we review (1) the key facets of mitochondrial biology that are relevant to the two conditions, and (2) the role that mitochondrial dysfunction plays in the shared pathophysiology. We posit that mitochondrial dysfunction lies at the root of the affected processes rather than alongside them as a co-pathology.

KW - Aging

KW - Alzheimer's disease

KW - Comorbidity

KW - Mitochondria

KW - Mitochondrial DNA

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85046117862&partnerID=8YFLogxK

U2 - 10.1016/j.mito.2018.04.004

DO - 10.1016/j.mito.2018.04.004

M3 - Review article

C2 - 29678670

AN - SCOPUS:85046117862

VL - 43

SP - 16

EP - 24

JO - Mitochondrion

JF - Mitochondrion

SN - 1567-7249

ER -