Abstract
Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.
Original language | English |
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Pages (from-to) | 161-165 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 1062 |
Issue number | 1-2 |
DOIs | |
State | Published - 16 Nov 2005 |
Keywords
- 5-HT receptor
- Drug discrimination
- Ethanol
- Rat
- m-Chlorophenylpiperazine