Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine

Michael B. Gatch

doi:10.1016/j.brainres.2005.09.030

Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine

Michael B. Gatch

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT_1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Brain Research
Volume	1062
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2005.09.030
State	Published - 16 Nov 2005

Keywords

5-HT receptor
Drug discrimination
Ethanol
Rat
m-Chlorophenylpiperazine

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abstract = "Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.",

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AB - Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.

KW - 5-HT receptor

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KW - Ethanol

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KW - m-Chlorophenylpiperazine

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Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine

Abstract

Keywords

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