Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine

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Abstract

Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalBrain Research
Volume1062
Issue number1-2
DOIs
StatePublished - 16 Nov 2005

Keywords

  • 5-HT receptor
  • Drug discrimination
  • Ethanol
  • Rat
  • m-Chlorophenylpiperazine

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