Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine

Michael B. Gatch

doi:10.1016/j.brainres.2005.09.030

Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine

Michael B. Gatch

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT_1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Brain Research
Volume	1062
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2005.09.030
State	Published - 16 Nov 2005

Keywords

5-HT receptor
Drug discrimination
Ethanol
Rat
m-Chlorophenylpiperazine

Access to Document

10.1016/j.brainres.2005.09.030

Cite this

@article{48c97201544144809b5d5c7182c91507,

title = "Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine",

abstract = "Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.",

keywords = "5-HT receptor, Drug discrimination, Ethanol, Rat, m-Chlorophenylpiperazine",

author = "Gatch, {Michael B.}",

year = "2005",

month = nov,

day = "16",

doi = "10.1016/j.brainres.2005.09.030",

language = "English",

volume = "1062",

pages = "161--165",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine

AU - Gatch, Michael B.

PY - 2005/11/16

Y1 - 2005/11/16

N2 - Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.

AB - Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT1/2 receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.

KW - 5-HT receptor

KW - Drug discrimination

KW - Ethanol

KW - Rat

KW - m-Chlorophenylpiperazine

UR - http://www.scopus.com/inward/record.url?scp=27744498391&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2005.09.030

DO - 10.1016/j.brainres.2005.09.030

M3 - Article

C2 - 16256082

AN - SCOPUS:27744498391

VL - 1062

SP - 161

EP - 165

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -

Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this