Estrogens and progesterone as neuroprotectants: What animal models teach us

Meharvan Singh, Nathalie Sumien, Cheryl Kyser, James W. Simpkins

Research output: Contribution to journalReview article

79 Citations (Scopus)

Abstract

Estradiol and progesterone are two steroid hormones that target a variety of organ systems, including the heart, the bone and the brain. With respect to the latter, a large volume of basic science studies support the neuroprotective role of estradiol and/or progesterone. In fact, the results of such studies prompted the assessment of these hormones as protective agents against such disorders as Alzheimer's disease, stroke and traumatic brain injury. Interestingly, results from the Women's Health Initiative (WHI) yielded results that appeared to be inconsistent with the data derived from in vitro and in vivo models. However, we argue that the results from the basic science studies were not inconsistent with the clinical trials, but rather, are consistent with, and may even have predicted, the results from the WHI. To illustrate this point, we review here certain in vivo paradigms that have been used to assess the protective effects of estrogens and progesterone, and describe how the results from these animal models point to the importance of the type of hormone, the age of the subjects and the method of hormone administration, in determining whether or not hormones are neuroprotective.

Original languageEnglish
Pages (from-to)1083-1089
Number of pages7
JournalFrontiers in Bioscience
Volume13
Issue number3
DOIs
StatePublished - 2 May 2008

Fingerprint

Neuroprotective Agents
Progesterone
Estrogens
Animals
Animal Models
Hormones
Women's Health
Estradiol
Brain
Steroid hormones
Protective Agents
Bone
Alzheimer Disease
Stroke
Steroids
Clinical Trials
Bone and Bones

Keywords

  • Alzheimer's disease
  • Animal models
  • Estrogens
  • Neuroprotection
  • Progestins
  • Review

Cite this

Singh, Meharvan ; Sumien, Nathalie ; Kyser, Cheryl ; Simpkins, James W. / Estrogens and progesterone as neuroprotectants : What animal models teach us. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 3. pp. 1083-1089.
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Estrogens and progesterone as neuroprotectants : What animal models teach us. / Singh, Meharvan; Sumien, Nathalie; Kyser, Cheryl; Simpkins, James W.

In: Frontiers in Bioscience, Vol. 13, No. 3, 02.05.2008, p. 1083-1089.

Research output: Contribution to journalReview article

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