Estrogen receptor pathways to AP-1

Peter J. Kushner, David A. Agard, Geoffrey L. Greene, Thomas S. Scanlan, Andrew K. Shiau, Rosalie Maire Uht, Paul Webb

Research output: Contribution to journalArticle

685 Citations (Scopus)

Abstract

Estrogen receptor (ER) binds to estrogen response elements in target genes and recruits a coactivator complex of CBP-pl60 that mediates stimulation of transcription. ER also activates transcription at AP-1 sites that bind the Jun/Fos transcription factors, but not ER. We review the evidence regarding mechanisms whereby ER increases the activity of Jun/Fos and propose two pathways of ER action depending on the ER (α or β) and on the ligand. We propose that estrogen-ERα complexes use their activation functions (AF-1 and AF-2) to bind to the p 160 component of the coactivator complex recruited by Jun/Fos and trigger the coactivator to a higher state of activity. We propose that selective estrogen receptor modulator (SERM) complexes with ERβ and with truncated ERα derivatives use their DNA binding domain to titrate histone deacetylase (HDAC)-repressor complexes away from the Jun/Fos coactivator complex, thereby allowing unfettered activity of the coactivators. Finally, we consider the possible physiological significance of ER action at AP-1 sites.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume74
Issue number5
DOIs
StatePublished - 30 Nov 2000

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Transcription Factor AP-1
Estrogen Receptors
Transcription
Estrogens
Furylfuramide
Selective Estrogen Receptor Modulators
Histone Deacetylases
Response Elements
Transcription Factors
Genes
Chemical activation
Ligands
Derivatives
DNA

Keywords

  • Coactivator
  • Estrogen receptor
  • Transcription factors

Cite this

Kushner, P. J., Agard, D. A., Greene, G. L., Scanlan, T. S., Shiau, A. K., Uht, R. M., & Webb, P. (2000). Estrogen receptor pathways to AP-1. Journal of Steroid Biochemistry and Molecular Biology, 74(5), 311-317. https://doi.org/10.1016/S0960-0760(00)00108-4
Kushner, Peter J. ; Agard, David A. ; Greene, Geoffrey L. ; Scanlan, Thomas S. ; Shiau, Andrew K. ; Uht, Rosalie Maire ; Webb, Paul. / Estrogen receptor pathways to AP-1. In: Journal of Steroid Biochemistry and Molecular Biology. 2000 ; Vol. 74, No. 5. pp. 311-317.
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Kushner, PJ, Agard, DA, Greene, GL, Scanlan, TS, Shiau, AK, Uht, RM & Webb, P 2000, 'Estrogen receptor pathways to AP-1', Journal of Steroid Biochemistry and Molecular Biology, vol. 74, no. 5, pp. 311-317. https://doi.org/10.1016/S0960-0760(00)00108-4

Estrogen receptor pathways to AP-1. / Kushner, Peter J.; Agard, David A.; Greene, Geoffrey L.; Scanlan, Thomas S.; Shiau, Andrew K.; Uht, Rosalie Maire; Webb, Paul.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 74, No. 5, 30.11.2000, p. 311-317.

Research output: Contribution to journalArticle

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AU - Kushner, Peter J.

AU - Agard, David A.

AU - Greene, Geoffrey L.

AU - Scanlan, Thomas S.

AU - Shiau, Andrew K.

AU - Uht, Rosalie Maire

AU - Webb, Paul

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