Estimation of time of divergence from phylogenetic studies

R. Chakraborty

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Abstract

Recent studies with comparative data on base sequences of homologous DNAs or amino acid sequences of homologous proteins indicate that simultaneous estimation of phylogenetic structure and time of divergence is often cumbersome and time consuming. On the other hand, when the topology of an evolutionary tree is known, it is shown in this paper that the least squares theory may be applied to obtain simple estimates of the relative time lengths for each segment of the tree under the assumption of uniform random substitutions in each segment. The method is illustrated with amino acid sequence data on various globin molecules and cytochrome c. The evolutionary significance of some of the estimates is also discussed.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalUnknown Journal
Volume19
Issue number2
DOIs
StatePublished - 1 Jan 1977

Fingerprint

amino acid sequences
cytochrome c
phylogeny
topology
least squares
Amino Acid Sequence Homology
Globins
Cytochromes c
Least-Squares Analysis
nucleotide sequences
Amino Acid Sequence
DNA
proteins
Proteins
methodology

Cite this

Chakraborty, R. / Estimation of time of divergence from phylogenetic studies. In: Unknown Journal. 1977 ; Vol. 19, No. 2. pp. 217-223.
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Estimation of time of divergence from phylogenetic studies. / Chakraborty, R.

In: Unknown Journal, Vol. 19, No. 2, 01.01.1977, p. 217-223.

Research output: Contribution to journalArticleResearchpeer-review

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