Estimation of time of divergence from phylogenetic studies

R. Chakraborty

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Recent studies with comparative data on base sequences of homologous DNAs or amino acid sequences of homologous proteins indicate that simultaneous estimation of phylogenetic structure and time of divergence is often cumbersome and time consuming. On the other hand, when the topology of an evolutionary tree is known, it is shown in this paper that the least squares theory may be applied to obtain simple estimates of the relative time lengths for each segment of the tree under the assumption of uniform random substitutions in each segment. The method is illustrated with amino acid sequence data on various globin molecules and cytochrome c. The evolutionary significance of some of the estimates is also discussed.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalUnknown Journal
Issue number2
StatePublished - 1 Jan 1977


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