Abstract
Simple estimators of gene frequencies and linkage disequilibria are proposed when haplotype data are available from four parental chromosomes of a child (or fetus) for whom genetic counseling is sought for a disease condition. The method is illustrated with restriction site polymorphisms associated with sickle-cell anemia (Hb-βS) gene as surveyed in genetic counseling data from American blacks. The method suggested here is shown to be useful in testing for the significance of interactions of site-specific variations of any order in the chromosomal region assayed.
Original language | English |
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Pages (from-to) | 323-333 |
Number of pages | 11 |
Journal | Genetic Epidemiology |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - 1 Jan 1986 |
Keywords
- allelic association
- genetic counseling
- restriction site polymorphism
- sickle-cell anemia