Estimation of linkage disequilibrium from conditional haplotype data: Application to β-globin gene cluster in American blacks

Ranajit Chakraborty

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Simple estimators of gene frequencies and linkage disequilibria are proposed when haplotype data are available from four parental chromosomes of a child (or fetus) for whom genetic counseling is sought for a disease condition. The method is illustrated with restriction site polymorphisms associated with sickle-cell anemia (Hb-βS) gene as surveyed in genetic counseling data from American blacks. The method suggested here is shown to be useful in testing for the significance of interactions of site-specific variations of any order in the chromosomal region assayed.

Original languageEnglish
Pages (from-to)323-333
Number of pages11
JournalGenetic Epidemiology
Volume3
Issue number5
DOIs
StatePublished - 1 Jan 1986

Keywords

  • allelic association
  • genetic counseling
  • restriction site polymorphism
  • sickle-cell anemia

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