Estimating the frequency of nonpaternity in Switzerland

G. Sasse, H. Muller, R. Chakraborty, J. Ott

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

In linkage analysis and gene mapping in general, typing error and/or errors in specifying pedigree relationships between individuals typically lead to an upwards bias in recombination fraction estimates and to a loss of power for detecting linkage. The presence of nonpaternity is the most common source of error of misspecification of pedigree relationships between individuals that can have a negative impact on pedigree analysis. We have developed estimates of underlying nonpaternity probabilities based on observed Mendelian inconsistencies. The methods were applied to a sample of 1,607 children and their parents. Genetic marker data were investigated to test for exclusions due to nonpaternity. Among the 1,607 children, 11 or 0.68% exclusions were found. When a constant nonpaternity rate was assumed for each child, its maximum likelihood estimate turned out to be 0.78% with asymptotic 95% confidence limits of 0.41% and 1.35%. When varying nonpaternity rates were assumed, its mean was estimated as 0.83% with asymptotic 95% confidence limits of 0.32% and 1.33%.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalHuman Heredity
Volume44
Issue number6
DOIs
StatePublished - 1 Jan 1994

Fingerprint

Pedigree
Switzerland
Chromosome Mapping
Likelihood Functions
Genetic Markers
Genetic Recombination
Research Design
Parents

Keywords

  • Exclusion probability
  • Maximum likelihood
  • Mendelian inconsistency
  • Nonpaternity

Cite this

Sasse, G., Muller, H., Chakraborty, R., & Ott, J. (1994). Estimating the frequency of nonpaternity in Switzerland. Human Heredity, 44(6), 337-343. https://doi.org/10.1159/000154241
Sasse, G. ; Muller, H. ; Chakraborty, R. ; Ott, J. / Estimating the frequency of nonpaternity in Switzerland. In: Human Heredity. 1994 ; Vol. 44, No. 6. pp. 337-343.
@article{93e014a2795a46989535ba7bdfed431c,
title = "Estimating the frequency of nonpaternity in Switzerland",
abstract = "In linkage analysis and gene mapping in general, typing error and/or errors in specifying pedigree relationships between individuals typically lead to an upwards bias in recombination fraction estimates and to a loss of power for detecting linkage. The presence of nonpaternity is the most common source of error of misspecification of pedigree relationships between individuals that can have a negative impact on pedigree analysis. We have developed estimates of underlying nonpaternity probabilities based on observed Mendelian inconsistencies. The methods were applied to a sample of 1,607 children and their parents. Genetic marker data were investigated to test for exclusions due to nonpaternity. Among the 1,607 children, 11 or 0.68{\%} exclusions were found. When a constant nonpaternity rate was assumed for each child, its maximum likelihood estimate turned out to be 0.78{\%} with asymptotic 95{\%} confidence limits of 0.41{\%} and 1.35{\%}. When varying nonpaternity rates were assumed, its mean was estimated as 0.83{\%} with asymptotic 95{\%} confidence limits of 0.32{\%} and 1.33{\%}.",
keywords = "Exclusion probability, Maximum likelihood, Mendelian inconsistency, Nonpaternity",
author = "G. Sasse and H. Muller and R. Chakraborty and J. Ott",
year = "1994",
month = "1",
day = "1",
doi = "10.1159/000154241",
language = "English",
volume = "44",
pages = "337--343",
journal = "Human Heredity",
issn = "0001-5652",
publisher = "S. Karger AG",
number = "6",

}

Sasse, G, Muller, H, Chakraborty, R & Ott, J 1994, 'Estimating the frequency of nonpaternity in Switzerland', Human Heredity, vol. 44, no. 6, pp. 337-343. https://doi.org/10.1159/000154241

Estimating the frequency of nonpaternity in Switzerland. / Sasse, G.; Muller, H.; Chakraborty, R.; Ott, J.

In: Human Heredity, Vol. 44, No. 6, 01.01.1994, p. 337-343.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Estimating the frequency of nonpaternity in Switzerland

AU - Sasse, G.

AU - Muller, H.

AU - Chakraborty, R.

AU - Ott, J.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - In linkage analysis and gene mapping in general, typing error and/or errors in specifying pedigree relationships between individuals typically lead to an upwards bias in recombination fraction estimates and to a loss of power for detecting linkage. The presence of nonpaternity is the most common source of error of misspecification of pedigree relationships between individuals that can have a negative impact on pedigree analysis. We have developed estimates of underlying nonpaternity probabilities based on observed Mendelian inconsistencies. The methods were applied to a sample of 1,607 children and their parents. Genetic marker data were investigated to test for exclusions due to nonpaternity. Among the 1,607 children, 11 or 0.68% exclusions were found. When a constant nonpaternity rate was assumed for each child, its maximum likelihood estimate turned out to be 0.78% with asymptotic 95% confidence limits of 0.41% and 1.35%. When varying nonpaternity rates were assumed, its mean was estimated as 0.83% with asymptotic 95% confidence limits of 0.32% and 1.33%.

AB - In linkage analysis and gene mapping in general, typing error and/or errors in specifying pedigree relationships between individuals typically lead to an upwards bias in recombination fraction estimates and to a loss of power for detecting linkage. The presence of nonpaternity is the most common source of error of misspecification of pedigree relationships between individuals that can have a negative impact on pedigree analysis. We have developed estimates of underlying nonpaternity probabilities based on observed Mendelian inconsistencies. The methods were applied to a sample of 1,607 children and their parents. Genetic marker data were investigated to test for exclusions due to nonpaternity. Among the 1,607 children, 11 or 0.68% exclusions were found. When a constant nonpaternity rate was assumed for each child, its maximum likelihood estimate turned out to be 0.78% with asymptotic 95% confidence limits of 0.41% and 1.35%. When varying nonpaternity rates were assumed, its mean was estimated as 0.83% with asymptotic 95% confidence limits of 0.32% and 1.33%.

KW - Exclusion probability

KW - Maximum likelihood

KW - Mendelian inconsistency

KW - Nonpaternity

UR - http://www.scopus.com/inward/record.url?scp=0028062086&partnerID=8YFLogxK

U2 - 10.1159/000154241

DO - 10.1159/000154241

M3 - Article

C2 - 7860087

AN - SCOPUS:0028062086

VL - 44

SP - 337

EP - 343

JO - Human Heredity

JF - Human Heredity

SN - 0001-5652

IS - 6

ER -

Sasse G, Muller H, Chakraborty R, Ott J. Estimating the frequency of nonpaternity in Switzerland. Human Heredity. 1994 Jan 1;44(6):337-343. https://doi.org/10.1159/000154241