Estimating the frequency of nonpaternity in Switzerland

G. Sasse, H. Muller, R. Chakraborty, J. Ott

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64 Scopus citations

Abstract

In linkage analysis and gene mapping in general, typing error and/or errors in specifying pedigree relationships between individuals typically lead to an upwards bias in recombination fraction estimates and to a loss of power for detecting linkage. The presence of nonpaternity is the most common source of error of misspecification of pedigree relationships between individuals that can have a negative impact on pedigree analysis. We have developed estimates of underlying nonpaternity probabilities based on observed Mendelian inconsistencies. The methods were applied to a sample of 1,607 children and their parents. Genetic marker data were investigated to test for exclusions due to nonpaternity. Among the 1,607 children, 11 or 0.68% exclusions were found. When a constant nonpaternity rate was assumed for each child, its maximum likelihood estimate turned out to be 0.78% with asymptotic 95% confidence limits of 0.41% and 1.35%. When varying nonpaternity rates were assumed, its mean was estimated as 0.83% with asymptotic 95% confidence limits of 0.32% and 1.33%.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalHuman heredity
Volume44
Issue number6
DOIs
StatePublished - 1 Jan 1994

Keywords

  • Exclusion probability
  • Maximum likelihood
  • Mendelian inconsistency
  • Nonpaternity

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    Sasse, G., Muller, H., Chakraborty, R., & Ott, J. (1994). Estimating the frequency of nonpaternity in Switzerland. Human heredity, 44(6), 337-343. https://doi.org/10.1159/000154241