Estimating minimum allele frequencies for DNA profile frequency estimates for PCR-based loci

B. Budowle, K. L. Monson, R. Chakraborty

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

In order that there can be confidence that DNA profile frequency estimates will not place undue bias against a defendant, 2 methods are described for estimating minimum allele frequency bounds for PCR-based loci. One approach estimates minimum allele frequencies for VNTR and STR loci using sample size and the observed heterozygosity at a locus, while the second approach, appropriate for loci typed with allele-specific oligonucleotide probes, is based only on sample size. The use of a minimum allele frequency enables compensation for sparse sampling of infrequent alleles in population databases.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalInternational journal of legal medicine
Volume108
Issue number4
DOIs
StatePublished - 1 Feb 1996

Keywords

  • Allele frequency
  • PM loci
  • Population data
  • STR
  • VNTR

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