Abstract
In order that there can be confidence that DNA profile frequency estimates will not place undue bias against a defendant, 2 methods are described for estimating minimum allele frequency bounds for PCR-based loci. One approach estimates minimum allele frequencies for VNTR and STR loci using sample size and the observed heterozygosity at a locus, while the second approach, appropriate for loci typed with allele-specific oligonucleotide probes, is based only on sample size. The use of a minimum allele frequency enables compensation for sparse sampling of infrequent alleles in population databases.
Original language | English |
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Pages (from-to) | 173-176 |
Number of pages | 4 |
Journal | International journal of legal medicine |
Volume | 108 |
Issue number | 4 |
DOIs | |
State | Published - Feb 1996 |
Keywords
- Allele frequency
- PM loci
- Population data
- STR
- VNTR