TY - JOUR
T1 - Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives
T2 - An Invitation to Collaborate
AU - Lesko, Lawrence J.
AU - Vozmediano, Valvanera
AU - Brown, Joshua D.
AU - Winterstein, Almut
AU - Zhao, Ping
AU - Lippert, Jörg
AU - Höchel, Joachim
AU - Chaturvedula, Ayyappa
AU - White, Annesha
AU - Schmidt, Stephan
N1 - Funding Information:
This work was supported by the Bill & Melinda Gates
Publisher Copyright:
© 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.
PY - 2018/11
Y1 - 2018/11
N2 - Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.
AB - Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.
UR - http://www.scopus.com/inward/record.url?scp=85055705925&partnerID=8YFLogxK
U2 - 10.1002/psp4.12357
DO - 10.1002/psp4.12357
M3 - Comment/debate
C2 - 30260082
AN - SCOPUS:85055705925
VL - 7
SP - 706
EP - 708
JO - CPT: Pharmacometrics and Systems Pharmacology
JF - CPT: Pharmacometrics and Systems Pharmacology
SN - 2163-8306
IS - 11
ER -