Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

Lawrence J. Lesko, Valvanera Vozmediano, Joshua D. Brown, Almut Winterstein, Ping Zhao, Jörg Lippert, Joachim Höchel, Ayyappa Chaturvedula, Annesha White, Stephan Schmidt

Research output: Contribution to journalComment/debate

3 Scopus citations


Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.

Original languageEnglish
Pages (from-to)706-708
Number of pages3
JournalCPT: Pharmacometrics and Systems Pharmacology
Issue number11
StatePublished - Nov 2018


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