Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives

An Invitation to Collaborate

Lawrence J. Lesko, Valvanera Vozmediano, Joshua D. Brown, Almut Winterstein, Ping Zhao, Jörg Lippert, Joachim Höchel, Ayyappa Chaturvedula, Annesha White, Stephan Schmidt

Research output: Contribution to journalComment/debateResearch

1 Citation (Scopus)

Abstract

Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.

Original languageEnglish
Pages (from-to)706-708
Number of pages3
JournalCPT: Pharmacometrics and Systems Pharmacology
Volume7
Issue number11
DOIs
StatePublished - 1 Nov 2018

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Drug interactions
Contraceptive Agents
Drug Interactions
Drugs
Interaction
Pharmaceutical Preparations
Metrorrhagia
Industry
Pregnancy
Research Personnel
Framework
Likely
Research
Prediction

Cite this

Lesko, Lawrence J. ; Vozmediano, Valvanera ; Brown, Joshua D. ; Winterstein, Almut ; Zhao, Ping ; Lippert, Jörg ; Höchel, Joachim ; Chaturvedula, Ayyappa ; White, Annesha ; Schmidt, Stephan. / Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives : An Invitation to Collaborate. In: CPT: Pharmacometrics and Systems Pharmacology. 2018 ; Vol. 7, No. 11. pp. 706-708.
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Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives : An Invitation to Collaborate. / Lesko, Lawrence J.; Vozmediano, Valvanera; Brown, Joshua D.; Winterstein, Almut; Zhao, Ping; Lippert, Jörg; Höchel, Joachim; Chaturvedula, Ayyappa; White, Annesha; Schmidt, Stephan.

In: CPT: Pharmacometrics and Systems Pharmacology, Vol. 7, No. 11, 01.11.2018, p. 706-708.

Research output: Contribution to journalComment/debateResearch

TY - JOUR

T1 - Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives

T2 - An Invitation to Collaborate

AU - Lesko, Lawrence J.

AU - Vozmediano, Valvanera

AU - Brown, Joshua D.

AU - Winterstein, Almut

AU - Zhao, Ping

AU - Lippert, Jörg

AU - Höchel, Joachim

AU - Chaturvedula, Ayyappa

AU - White, Annesha

AU - Schmidt, Stephan

PY - 2018/11/1

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AB - Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.

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JO - CPT: Pharmacometrics and Systems Pharmacology

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