Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

Lawrence J. Lesko; Valvanera Vozmediano; Joshua D. Brown; Almut Winterstein; Ping Zhao; Jörg Lippert; Joachim Höchel; Ayyappa Chaturvedula; Annesha White; Stephan Schmidt

doi:10.1002/psp4.12357

Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

Lawrence J. Lesko, Valvanera Vozmediano, Joshua D. Brown, Almut Winterstein, Ping Zhao, Jörg Lippert, Joachim Höchel, Ayyappa Chaturvedula, Annesha White, Stephan Schmidt

Research output: Contribution to journal › Comment/debate

8 Scopus citations

Abstract

Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.

Original language	English
Pages (from-to)	706-708
Number of pages	3
Journal	CPT: Pharmacometrics and Systems Pharmacology
Volume	7
Issue number	11
DOIs	https://doi.org/10.1002/psp4.12357
State	Published - Nov 2018

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Lesko, L. J., Vozmediano, V., Brown, J. D., Winterstein, A., Zhao, P., Lippert, J., Höchel, J., Chaturvedula, A., White, A., & Schmidt, S. (2018). Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate. CPT: Pharmacometrics and Systems Pharmacology, 7(11), 706-708. https://doi.org/10.1002/psp4.12357

Lesko, Lawrence J. ; Vozmediano, Valvanera ; Brown, Joshua D. ; Winterstein, Almut ; Zhao, Ping ; Lippert, Jörg ; Höchel, Joachim ; Chaturvedula, Ayyappa ; White, Annesha ; Schmidt, Stephan. / Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives : An Invitation to Collaborate. In: CPT: Pharmacometrics and Systems Pharmacology. 2018 ; Vol. 7, No. 11. pp. 706-708.

@article{2f4a1080180c4bce9dcf04dfe5a69c0f,

title = "Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate",

abstract = "Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.",

author = "Lesko, {Lawrence J.} and Valvanera Vozmediano and Brown, {Joshua D.} and Almut Winterstein and Ping Zhao and J{\"o}rg Lippert and Joachim H{\"o}chel and Ayyappa Chaturvedula and Annesha White and Stephan Schmidt",

note = "Funding Information: This work was supported by the Bill & Melinda Gates Publisher Copyright: {\textcopyright} 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2018",

month = nov,

doi = "10.1002/psp4.12357",

language = "English",

volume = "7",

pages = "706--708",

journal = "CPT: Pharmacometrics and Systems Pharmacology",

issn = "2163-8306",

publisher = "Wiley-Blackwell",

number = "11",

}

Lesko, LJ, Vozmediano, V, Brown, JD, Winterstein, A, Zhao, P, Lippert, J, Höchel, J, Chaturvedula, A , White, A & Schmidt, S 2018, 'Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate', CPT: Pharmacometrics and Systems Pharmacology, vol. 7, no. 11, pp. 706-708. https://doi.org/10.1002/psp4.12357

Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives : An Invitation to Collaborate. / Lesko, Lawrence J.; Vozmediano, Valvanera; Brown, Joshua D.; Winterstein, Almut; Zhao, Ping; Lippert, Jörg; Höchel, Joachim; Chaturvedula, Ayyappa ; White, Annesha; Schmidt, Stephan.

In: CPT: Pharmacometrics and Systems Pharmacology, Vol. 7, No. 11, 11.2018, p. 706-708.

Research output: Contribution to journal › Comment/debate

TY - JOUR

T1 - Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives

T2 - An Invitation to Collaborate

AU - Lesko, Lawrence J.

AU - Vozmediano, Valvanera

AU - Brown, Joshua D.

AU - Winterstein, Almut

AU - Zhao, Ping

AU - Lippert, Jörg

AU - Höchel, Joachim

AU - Chaturvedula, Ayyappa

AU - White, Annesha

AU - Schmidt, Stephan

N1 - Funding Information: This work was supported by the Bill & Melinda Gates Publisher Copyright: © 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2018/11

Y1 - 2018/11

N2 - Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.

AB - Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.

UR - http://www.scopus.com/inward/record.url?scp=85055705925&partnerID=8YFLogxK

U2 - 10.1002/psp4.12357

DO - 10.1002/psp4.12357

M3 - Comment/debate

C2 - 30260082

AN - SCOPUS:85055705925

VL - 7

SP - 706

EP - 708

JO - CPT: Pharmacometrics and Systems Pharmacology

JF - CPT: Pharmacometrics and Systems Pharmacology

SN - 2163-8306

IS - 11

ER -

Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

Abstract

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