Environmental and dietary risk factors in Alzheimer's disease

Remi Dosunmu; Jinfang Wu; Md Riyaz Basha; Nasser H. Zawia

doi:10.1586/14737175.7.7.887

Environmental and dietary risk factors in Alzheimer's disease

Remi Dosunmu, Jinfang Wu, Md Riyaz Basha, Nasser H. Zawia

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects millions in the aging population worldwide and will affect millions more in the next 20 years. Over 90% of all cases are sporadic, with genetics playing a minor role in the etiology of AD. Therefore, it is crucial to investigate the environment and diet as primary risk factors in AD pathology. This review considers epidemiologic case control studies, and in vitro and in vivo research to investigate the potential of environmental exposure to metals, air pollution and pesticides as well as diet as risk factors for AD. In some cases, the role of genetic mutations and environmental risk is discussed. The evidence examined in this review provides a brief overview of the current literature on selected, significant risk factors in promoting amyloid-β accumulation and aggregation, thus contributing to neurodegeneration.

Original language	English
Pages (from-to)	887-900
Number of pages	14
Journal	Expert Review of Neurotherapeutics
Volume	7
Issue number	7
DOIs	https://doi.org/10.1586/14737175.7.7.887
State	Published - Jul 2007

Keywords

Alzheimer's disease
Amyloid-β
Diet
Lead
Risk factor

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10.1586/14737175.7.7.887

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@article{15abd5f6e6ef445cb5faeb4ca9e052c1,

title = "Environmental and dietary risk factors in Alzheimer's disease",

abstract = "Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects millions in the aging population worldwide and will affect millions more in the next 20 years. Over 90% of all cases are sporadic, with genetics playing a minor role in the etiology of AD. Therefore, it is crucial to investigate the environment and diet as primary risk factors in AD pathology. This review considers epidemiologic case control studies, and in vitro and in vivo research to investigate the potential of environmental exposure to metals, air pollution and pesticides as well as diet as risk factors for AD. In some cases, the role of genetic mutations and environmental risk is discussed. The evidence examined in this review provides a brief overview of the current literature on selected, significant risk factors in promoting amyloid-β accumulation and aggregation, thus contributing to neurodegeneration.",

keywords = "Alzheimer's disease, Amyloid-β, Diet, Lead, Risk factor",

author = "Remi Dosunmu and Jinfang Wu and Basha, {Md Riyaz} and Zawia, {Nasser H.}",

note = "Funding Information: The research work in the authors{\textquoteright} laboratory is made possible by the grants (ES013022 and AG027246) from the NIH awarded to NH Zawia. The research core facility was funded (P20RR016457) by the National Center for Research Resources (NCRR), a component of NIH.",

year = "2007",

month = jul,

doi = "10.1586/14737175.7.7.887",

language = "English",

volume = "7",

pages = "887--900",

journal = "Expert Review of Neurotherapeutics",

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T1 - Environmental and dietary risk factors in Alzheimer's disease

AU - Dosunmu, Remi

AU - Wu, Jinfang

AU - Basha, Md Riyaz

AU - Zawia, Nasser H.

N1 - Funding Information: The research work in the authors’ laboratory is made possible by the grants (ES013022 and AG027246) from the NIH awarded to NH Zawia. The research core facility was funded (P20RR016457) by the National Center for Research Resources (NCRR), a component of NIH.

PY - 2007/7

Y1 - 2007/7

N2 - Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects millions in the aging population worldwide and will affect millions more in the next 20 years. Over 90% of all cases are sporadic, with genetics playing a minor role in the etiology of AD. Therefore, it is crucial to investigate the environment and diet as primary risk factors in AD pathology. This review considers epidemiologic case control studies, and in vitro and in vivo research to investigate the potential of environmental exposure to metals, air pollution and pesticides as well as diet as risk factors for AD. In some cases, the role of genetic mutations and environmental risk is discussed. The evidence examined in this review provides a brief overview of the current literature on selected, significant risk factors in promoting amyloid-β accumulation and aggregation, thus contributing to neurodegeneration.

AB - Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects millions in the aging population worldwide and will affect millions more in the next 20 years. Over 90% of all cases are sporadic, with genetics playing a minor role in the etiology of AD. Therefore, it is crucial to investigate the environment and diet as primary risk factors in AD pathology. This review considers epidemiologic case control studies, and in vitro and in vivo research to investigate the potential of environmental exposure to metals, air pollution and pesticides as well as diet as risk factors for AD. In some cases, the role of genetic mutations and environmental risk is discussed. The evidence examined in this review provides a brief overview of the current literature on selected, significant risk factors in promoting amyloid-β accumulation and aggregation, thus contributing to neurodegeneration.

KW - Alzheimer's disease

KW - Amyloid-β

KW - Diet

KW - Lead

KW - Risk factor

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U2 - 10.1586/14737175.7.7.887

DO - 10.1586/14737175.7.7.887

M3 - Review article

C2 - 17610395

AN - SCOPUS:34447115078

SN - 1473-7175

VL - 7

SP - 887

EP - 900

JO - Expert Review of Neurotherapeutics

JF - Expert Review of Neurotherapeutics

IS - 7

ER -

Environmental and dietary risk factors in Alzheimer's disease

Abstract

Keywords

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