Abstract
Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.
| Original language | English |
|---|---|
| Pages (from-to) | 578-581 |
| Number of pages | 4 |
| Journal | Unknown Journal |
| Volume | 132 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1 Jan 1975 |
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Enhanced host defense mechanisms with levamisole in suckling rats. / Fischer, Gerald W.; Podgore, John; Bass, James W.; Kelley, James L.; Kobayashi, Glenn Y.
In: Unknown Journal, Vol. 132, No. 5, 01.01.1975, p. 578-581.Research output: Contribution to journal › Article
TY - JOUR
T1 - Enhanced host defense mechanisms with levamisole in suckling rats
AU - Fischer, Gerald W.
AU - Podgore, John
AU - Bass, James W.
AU - Kelley, James L.
AU - Kobayashi, Glenn Y.
PY - 1975/1/1
Y1 - 1975/1/1
N2 - Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.
AB - Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.
UR - http://www.scopus.com/inward/record.url?scp=0016711343&partnerID=8YFLogxK
U2 - 10.1093/infdis/132.5.578
DO - 10.1093/infdis/132.5.578
M3 - Article
C2 - 171323
AN - SCOPUS:0016711343
VL - 132
SP - 578
EP - 581
JO - Unknown Journal
JF - Unknown Journal
IS - 5
ER -