Enhanced host defense mechanisms with levamisole in suckling rats

Gerald W. Fischer; John K. Podgore; James W. Bass; James L. Kelley; Glenn Y. Kobayashi

doi:10.1093/infdis/132.5.578

Enhanced host defense mechanisms with levamisole in suckling rats

Gerald W. Fischer, John K. Podgore, James W. Bass, James L. Kelley, Glenn Y. Kobayashi

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32 Scopus citations

Abstract

Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.

Original language	English
Pages (from-to)	578-581
Number of pages	4
Journal	Unknown Journal
Volume	132
Issue number	5
DOIs	https://doi.org/10.1093/infdis/132.5.578
State	Published - 1 Jan 1975

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abstract = "Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.",

author = "Fischer, {Gerald W.} and Podgore, {John K.} and Bass, {James W.} and Kelley, {James L.} and Kobayashi, {Glenn Y.}",

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AU - Podgore, John K.

AU - Bass, James W.

AU - Kelley, James L.

AU - Kobayashi, Glenn Y.

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AB - Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.

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Enhanced host defense mechanisms with levamisole in suckling rats

Abstract

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