Enhanced host defense mechanisms with levamisole in suckling rats

Gerald W. Fischer, John Podgore, James W. Bass, James L. Kelley, Glenn Y. Kobayashi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.

Original languageEnglish
Pages (from-to)578-581
Number of pages4
JournalUnknown Journal
Volume132
Issue number5
DOIs
StatePublished - 1 Jan 1975

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Levamisole
Simplexvirus
Antiviral Agents
Staphylococcus aureus
Bacteria
In Vitro Techniques

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Fischer, G. W., Podgore, J., Bass, J. W., Kelley, J. L., & Kobayashi, G. Y. (1975). Enhanced host defense mechanisms with levamisole in suckling rats. Unknown Journal, 132(5), 578-581. https://doi.org/10.1093/infdis/132.5.578
Fischer, Gerald W. ; Podgore, John ; Bass, James W. ; Kelley, James L. ; Kobayashi, Glenn Y. / Enhanced host defense mechanisms with levamisole in suckling rats. In: Unknown Journal. 1975 ; Vol. 132, No. 5. pp. 578-581.
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Fischer, GW, Podgore, J, Bass, JW, Kelley, JL & Kobayashi, GY 1975, 'Enhanced host defense mechanisms with levamisole in suckling rats', Unknown Journal, vol. 132, no. 5, pp. 578-581. https://doi.org/10.1093/infdis/132.5.578

Enhanced host defense mechanisms with levamisole in suckling rats. / Fischer, Gerald W.; Podgore, John; Bass, James W.; Kelley, James L.; Kobayashi, Glenn Y.

In: Unknown Journal, Vol. 132, No. 5, 01.01.1975, p. 578-581.

Research output: Contribution to journalArticle

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