Enhanced host defense mechanisms with levamisole in suckling rats

Gerald W. Fischer, John K. Podgore, James W. Bass, James L. Kelley, Glenn Y. Kobayashi

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Abstract

Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.

Original languageEnglish
Pages (from-to)578-581
Number of pages4
JournalUnknown Journal
Volume132
Issue number5
DOIs
Publication statusPublished - 1 Jan 1975

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Fischer, G. W., Podgore, J. K., Bass, J. W., Kelley, J. L., & Kobayashi, G. Y. (1975). Enhanced host defense mechanisms with levamisole in suckling rats. Unknown Journal, 132(5), 578-581. https://doi.org/10.1093/infdis/132.5.578