Endothelin

Is it a contributor to glaucoma pathophysiology?

Research output: Contribution to journalReview articleResearchpeer-review

124 Citations (Scopus)

Abstract

Endothelin is a vasoactive peptide that has been shown to play an important role in vascular homeostasis. Recently, endothelin and its receptors have been found in ocular tissues where it appears to have a regulatory function. Endothelin is found in both the aqueous and vitreous humors and its concentration is elevated in glaucoma patients and in animal models of glaucoma. In the current review, the authors present information about the distribution of endothelin and endothelin receptors in the eye and the ocular actions of endothelins. Specifically, endothelin/aqueous humor dynamics, endothelin/nitric oxide interactions, endothelin and ischemia, and endothelin/optic nerve head effects. Observations concerning the potential role of endothelin in glaucoma pathophysiology is presented and discussed relative to its effects on the optic nerve head and in relation to glaucoma theories.

Original languageEnglish
Pages (from-to)259-270
Number of pages12
JournalJournal of Glaucoma
Volume11
Issue number3
DOIs
StatePublished - 1 Jan 2002

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Endothelins
Glaucoma
Endothelin Receptors
Aqueous Humor
Optic Disk
Vitreous Body
Information Dissemination
Blood Vessels
Nitric Oxide
Homeostasis
Ischemia
Animal Models
Peptides

Keywords

  • Endothelin
  • Glaucoma
  • Ocular neuropathy

Cite this

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title = "Endothelin: Is it a contributor to glaucoma pathophysiology?",
abstract = "Endothelin is a vasoactive peptide that has been shown to play an important role in vascular homeostasis. Recently, endothelin and its receptors have been found in ocular tissues where it appears to have a regulatory function. Endothelin is found in both the aqueous and vitreous humors and its concentration is elevated in glaucoma patients and in animal models of glaucoma. In the current review, the authors present information about the distribution of endothelin and endothelin receptors in the eye and the ocular actions of endothelins. Specifically, endothelin/aqueous humor dynamics, endothelin/nitric oxide interactions, endothelin and ischemia, and endothelin/optic nerve head effects. Observations concerning the potential role of endothelin in glaucoma pathophysiology is presented and discussed relative to its effects on the optic nerve head and in relation to glaucoma theories.",
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Endothelin : Is it a contributor to glaucoma pathophysiology? / Yorio, Thomas; Krishnamoorthy, Raghu; Prasanna, Ganesh.

In: Journal of Glaucoma, Vol. 11, No. 3, 01.01.2002, p. 259-270.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Krishnamoorthy, Raghu

AU - Prasanna, Ganesh

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