Endoperoxidation, hyperprostaglandinemia, and hyperlipidemia in a case of erythrophagocytic lymphohistiocytosis. Reversal with VP‐16 and indomethacin

R. E. Brown; W. P. Bowman; C. A. D'Cruzmd; T. E. Pick; J. E. Champion

doi:10.1002/1097-0142(19871115)60:10<2388::AID-CNCR2820601007>3.0.CO;2-A

Endoperoxidation, hyperprostaglandinemia, and hyperlipidemia in a case of erythrophagocytic lymphohistiocytosis. Reversal with VP‐16 and indomethacin

R. E. Brown, W. P. Bowman, C. A. D'Cruzmd, T. E. Pick, J. E. Champion

Pediatrics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Clinicopathologic and histopathologic evidence of both endoperoxidation with hyperprostaglandinemia and hyperlipidemia in a 5‐week‐old infant with a hemophagocytic syndrome is reported. Institution of histiocytolytic (VP‐16) and cyclo‐oxygenase inhibitor (indomethacin) therapies returned the prostaglandin levels and lipid profile to a nearly normal state coincidental with clinical recovery. It appears that by reducing the cell mass of histiocytes and controlling the over‐production of prostaglandins, some types of hemophagocytic syndrome can be reversed.

Original language	English
Pages (from-to)	2388-2393
Number of pages	6
Journal	Cancer
Volume	60
Issue number	10
DOIs	https://doi.org/10.1002/1097-0142(19871115)60:10<2388::AID-CNCR2820601007>3.0.CO;2-A
State	Published - 15 Nov 1987

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10.1002/1097-0142(19871115)60:10<2388::AID-CNCR2820601007>3.0.CO;2-A

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title = "Endoperoxidation, hyperprostaglandinemia, and hyperlipidemia in a case of erythrophagocytic lymphohistiocytosis. Reversal with VP‐16 and indomethacin",

abstract = "Clinicopathologic and histopathologic evidence of both endoperoxidation with hyperprostaglandinemia and hyperlipidemia in a 5‐week‐old infant with a hemophagocytic syndrome is reported. Institution of histiocytolytic (VP‐16) and cyclo‐oxygenase inhibitor (indomethacin) therapies returned the prostaglandin levels and lipid profile to a nearly normal state coincidental with clinical recovery. It appears that by reducing the cell mass of histiocytes and controlling the over‐production of prostaglandins, some types of hemophagocytic syndrome can be reversed.",

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year = "1987",

month = nov,

day = "15",

doi = "10.1002/1097-0142(19871115)60:10<2388::AID-CNCR2820601007>3.0.CO;2-A",

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TY - JOUR

T1 - Endoperoxidation, hyperprostaglandinemia, and hyperlipidemia in a case of erythrophagocytic lymphohistiocytosis. Reversal with VP‐16 and indomethacin

AU - Brown, R. E.

AU - Bowman, W. P.

AU - D'Cruzmd, C. A.

AU - Pick, T. E.

AU - Champion, J. E.

PY - 1987/11/15

Y1 - 1987/11/15

N2 - Clinicopathologic and histopathologic evidence of both endoperoxidation with hyperprostaglandinemia and hyperlipidemia in a 5‐week‐old infant with a hemophagocytic syndrome is reported. Institution of histiocytolytic (VP‐16) and cyclo‐oxygenase inhibitor (indomethacin) therapies returned the prostaglandin levels and lipid profile to a nearly normal state coincidental with clinical recovery. It appears that by reducing the cell mass of histiocytes and controlling the over‐production of prostaglandins, some types of hemophagocytic syndrome can be reversed.

AB - Clinicopathologic and histopathologic evidence of both endoperoxidation with hyperprostaglandinemia and hyperlipidemia in a 5‐week‐old infant with a hemophagocytic syndrome is reported. Institution of histiocytolytic (VP‐16) and cyclo‐oxygenase inhibitor (indomethacin) therapies returned the prostaglandin levels and lipid profile to a nearly normal state coincidental with clinical recovery. It appears that by reducing the cell mass of histiocytes and controlling the over‐production of prostaglandins, some types of hemophagocytic syndrome can be reversed.

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AN - SCOPUS:0023628539

SN - 0008-543X

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JO - Cancer

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ER -

Endoperoxidation, hyperprostaglandinemia, and hyperlipidemia in a case of erythrophagocytic lymphohistiocytosis. Reversal with VP‐16 and indomethacin

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