Abstract
Clinicopathologic and histopathologic evidence of both endoperoxidation with hyperprostaglandinemia and hyperlipidemia in a 5‐week‐old infant with a hemophagocytic syndrome is reported. Institution of histiocytolytic (VP‐16) and cyclo‐oxygenase inhibitor (indomethacin) therapies returned the prostaglandin levels and lipid profile to a nearly normal state coincidental with clinical recovery. It appears that by reducing the cell mass of histiocytes and controlling the over‐production of prostaglandins, some types of hemophagocytic syndrome can be reversed.
Original language | English |
---|---|
Pages (from-to) | 2388-2393 |
Number of pages | 6 |
Journal | Cancer |
Volume | 60 |
Issue number | 10 |
DOIs | |
State | Published - 15 Nov 1987 |