Elevated frequency of Tay-Sachs disease mong Ashkenazic Jews unlikely by genetic drift alone

A. Chakravarti, Ranajit Chakraborty

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Using the steady-state distribution of a recessive lethal gene the probability of finding the elevated frequency of Tay-Sachs (TSD) gene among Ashkenazic Jews is computed. For various estimated values of mutation rate and population size, this probability is found to be statistically significant. This probability, in fact, becomes even smaller if a steady influx of foreign genes into the Ashkenazic Jewish populations is considered. It is suggested that heterozygote advantage together with random genetic drift should be considered as the most probable mechanism for the elevation of TSD gene frequency among the Ashkenazic Jews.

Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalAmerican Journal of Human Genetics
Volume30
Issue number3
StatePublished - 1 Jan 1978

Fingerprint

Tay-Sachs Disease
Genetic Drift
Jews
Lethal Genes
Recessive Genes
Mutation Rate
Heterozygote
Population Density
Gene Frequency
Genes
Population

Cite this

Chakravarti, A. ; Chakraborty, Ranajit. / Elevated frequency of Tay-Sachs disease mong Ashkenazic Jews unlikely by genetic drift alone. In: American Journal of Human Genetics. 1978 ; Vol. 30, No. 3. pp. 256-261.
@article{c8af63b6f2644511a87b2beb63237687,
title = "Elevated frequency of Tay-Sachs disease mong Ashkenazic Jews unlikely by genetic drift alone",
abstract = "Using the steady-state distribution of a recessive lethal gene the probability of finding the elevated frequency of Tay-Sachs (TSD) gene among Ashkenazic Jews is computed. For various estimated values of mutation rate and population size, this probability is found to be statistically significant. This probability, in fact, becomes even smaller if a steady influx of foreign genes into the Ashkenazic Jewish populations is considered. It is suggested that heterozygote advantage together with random genetic drift should be considered as the most probable mechanism for the elevation of TSD gene frequency among the Ashkenazic Jews.",
author = "A. Chakravarti and Ranajit Chakraborty",
year = "1978",
month = "1",
day = "1",
language = "English",
volume = "30",
pages = "256--261",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "3",

}

Elevated frequency of Tay-Sachs disease mong Ashkenazic Jews unlikely by genetic drift alone. / Chakravarti, A.; Chakraborty, Ranajit.

In: American Journal of Human Genetics, Vol. 30, No. 3, 01.01.1978, p. 256-261.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Elevated frequency of Tay-Sachs disease mong Ashkenazic Jews unlikely by genetic drift alone

AU - Chakravarti, A.

AU - Chakraborty, Ranajit

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Using the steady-state distribution of a recessive lethal gene the probability of finding the elevated frequency of Tay-Sachs (TSD) gene among Ashkenazic Jews is computed. For various estimated values of mutation rate and population size, this probability is found to be statistically significant. This probability, in fact, becomes even smaller if a steady influx of foreign genes into the Ashkenazic Jewish populations is considered. It is suggested that heterozygote advantage together with random genetic drift should be considered as the most probable mechanism for the elevation of TSD gene frequency among the Ashkenazic Jews.

AB - Using the steady-state distribution of a recessive lethal gene the probability of finding the elevated frequency of Tay-Sachs (TSD) gene among Ashkenazic Jews is computed. For various estimated values of mutation rate and population size, this probability is found to be statistically significant. This probability, in fact, becomes even smaller if a steady influx of foreign genes into the Ashkenazic Jewish populations is considered. It is suggested that heterozygote advantage together with random genetic drift should be considered as the most probable mechanism for the elevation of TSD gene frequency among the Ashkenazic Jews.

UR - http://www.scopus.com/inward/record.url?scp=0017840866&partnerID=8YFLogxK

M3 - Article

VL - 30

SP - 256

EP - 261

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 3

ER -